Toxicity (NCI-CTC grade)
|
Standard therapy group (n = 50)
|
Intensive therapy group (n = 6)
|
---|
Grade 1
|
Grade 2
|
Grade 3
|
Grade 4
|
Grade 1
|
Grade 2
|
Grade 3
|
Grade 4
|
---|
Thrombocytopenia
|
18 (36.0)
|
1 (2.0)
|
0 (0)
|
0 (0)
|
0 (0)
|
1 (16.7)
|
0 (0)
|
0 (0)
|
Anemia
|
15 (30.0)
|
14 (28.0)
|
3 (6.0)
|
0 (0)
|
0 (0)
|
2 (33.3)
|
0 (0)
|
0 (0)
|
Nausea
|
15 (30.0)
|
9 (18.0)
|
0 (0)
|
0 (0)
|
2 (33.3)
|
1 (16.7)
|
0 (0)
|
0 (0)
|
Peripheral neurotoxicity
|
13 (26.0)
|
14 (28.0)
|
0 (0)
|
0 (0)
|
2 (33.3)
|
1 (16.7)
|
0 (0)
|
0 (0)
|
Astenia
|
11 (22.0)
|
11 (22.0)
|
1 (2.0)
|
0 (0)
|
0 (0)
|
1 (16.7)
|
0 (0)
|
0 (0)
|
Vomiting
|
10 (20.0)
|
5 (10.0)
|
0 (0)
|
0 (0)
|
2 (33.3)
|
0 (0)
|
0 (0)
|
0 (0)
|
Diarrhea
|
10 (20.0)
|
4 (8.0)
|
0 (0)
|
0 (0)
|
2 (33.3)
|
1 (16.7)
|
0 (0)
|
0 (0)
|
Neutropenia
|
10 (20.0)
|
13 (26.0)
|
15 (30.0)
|
6 (12.0)
|
0 (0)
|
2 (33.3)
|
1 (16.7)
|
1 (16.7)
|
Stomatitis
|
9 (18.0)
|
5 (10.0)
|
0 (0)
|
0 (0)
|
1 (16.7)
|
0 (0)
|
0 (0)
|
0 (0)
|
Hypertension
|
3 (6.0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
Hemorrhage
|
3 (6.0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
- All values are presented as number of patients followed by percentage in parentheses
-
FOLFOXIRI 5-fluorouracil, leucovorin, oxaliplatin, and irinotecan, NCI-CTC National Cancer Institute Common Toxicity Criteria