Fig. 6

Overexpression of TRIM3 suppressed migration and invasion of HepG2 and Bel-7402 cells. Representative images of cell invasion and migration are shown on the left (×100 magnification), and quantification of migrated or invaded cells in 10 randomly selected fields are shown on the right. a, b TRIM3 overexpression inhibited migration of HepG2 (a) and Bel-7402 (b) cells. c, d TRIM3 overexpression significantly attenuated invasion of HepG2 (c) and Bel-7402 (d) cells. Data are shown as mean  ±  SD of three independent experiments. P values were calculated using Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001, versus cell transfected with LV-NC