From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review
Marker | References | Sample size | Clinical stage | OS | DFS | Analytic methods | ||||
---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |||||
PKM2 | Zhan et al. [17] | 210 | I–IV | 1.748 | 1.277–2.395 | <0.001 | – | – | – | Cox proportional hazards model |
Li et al. [24] | 141 | I–IV | 1.214 | 0.728–2.026 | 0.458 | – | – | – | Cox proportional hazards model | |
Zhang et al. [95] | 86 | I–IV | 2.358 | 1.156–4.812 | 0.018 | – | – | – | Cox proportional hazards model | |
Fukuda et al. [96] | 205 | I–IV | 1.850 | 1.200–2.780 | 0.0189 | – | – | – | Cox proportional hazards model | |
CXCR4 | Gockel et al. [25] | 53 | I–III | 1.472 | 0.836–2.593 | 0.181 | – | – | – | Cox proportional hazards model |
Zhang et al. [98] | 136 | I–IV | 1.612 | 1.072–2.425 | 0.022 | 1.708 | 1.126–2.591 | 0.012 | Cox proportional hazards model | |
Lu et al. [99] | 127 | I–III | 1.720 | 0.749–3.928 | 0.202 | 1.497 | 0.659–3.399 | 0.335 | Cox proportional hazards model | |
Qi et al. [100] | 60 | – | – | – | 0.001 | – | – | – | Log-rank test | |
Sasaki et al. [101] | 214 | I–IV | – | – | 0.4 | – | – | 0.3 | Log-rank test | |
MLH1 | Tzao et al. [18] | 60 | I–IV | – | – | 0.18 | – | – | – | Log-rank test |
Kishi et al. [104] | 156 | I–IV | 2.020 | 1.146–4.231 | 0.018 | – | – | – | Cox proportional hazards model | |
Uehara et al. [105] | 122 | I–IV | – | – | 0.0043 | – | – | – | Log-rank test |