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Table 6 Prognostic markers involved in activating invasion and metastasis of ESCC as reported in original studies

From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Marker

References

Sample size

Clinical stage

OS

DFS

Analytic methods

HR

95% CI

P value

HR

95% CI

P value

E-cadherin

Ozawa et al. [79]

83

I–IV

0.022

0.003

Log-rank test

α-catenin

Nakanishi et al. [22]

96

I–III

0.741

0.160–3.450

0.70

Cox proportional hazards model

Nair et al. [26]

100

I–III

>0.05

Log-rank test

Setoyama et al. [80]

205

I–IV

0.468

0.314–0.664

<0.001

Cox proportional hazards model

Lin et al. [81]

62

I–III

>0.05

Log-rank test

β-catenin

Lv et al. [23]

70

I–IV

0.034

0.009–0.144

0.002

Cox proportional hazards model

Nair et al. [26]

100

I–III

>0.05

Log-rank test

Chang et al. [62]

118

I–IV

>0.05

Log-rank test

Lin et al. [81]

62

I–III

>0.05

Log-rank test

Situ et al. [82]

227

II

1.642

1.159–2.327

0.005

Cox proportional hazards model

Hsu et al. [83]

68

I–V

0.433

0.244–0.765

0.004 (membrane)

Cox proportional hazards model

0.821 (cytoplasm)

Zhao et al. [84]

106

I–IV

>0.05

Log-rank test

Li et al. [85]

128

I–IV

0.569

0.503

Log-rank test

Deng et al. [86]

100

0.872

Log-rank test

Podoplanin

Tong et al. [16]

56

I–IV

13.83

3.06–62.43

0.001

Cox proportional hazards model

Chao et al. [87]

113

II–IV

1.951

1.231–3.090

0.004

Cox proportional hazards model

Nakashima et al. [88]

101

I–IV

2.16

1.05–4.65

0.036

Cox proportional hazards model

Tanaka et al. [89]

139

I–III

3.084

1.543–6.164

0.001

Cox proportional hazards model

Rahadiani et al. [90]

61

I–IV

1.926

1.085–3.421

0.0253

1.931

1.087–3.431

0.0249

Cox proportional hazards model (univariate)

Fascin

Cao et al. [29]

315

I–IV

1.749

1.065–2.873

0.027

Cox proportional hazards model

Hashimoto et al. [91]

200

I–IV

1.79

1.15–2.77

0.0094

Cox proportional hazards model

Zhao et al. [92]

254

I–IV

1.604

1.145–2.248

0.006

Cox proportional hazards model

Takikita et al. [93]

257

I–IV

1.06

0.76–1.48

0.72

Cox proportional hazards model

  1. No original studies on the prognostic significance of metastasis-associated protein 1 (MTA1) in ESCC were reported after the meta-analyses. Therefore, MTA1 is not listed
  2. ESCC esophageal squamous cell carcinoma; OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval, no data