Table 6 Prognostic markers involved in activating invasion and metastasis of ESCC as reported in original studies
From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review
Marker | References | Sample size | Clinical stage | OS | DFS | Analytic methods | ||||
|---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |||||
E-cadherin | Ozawa et al. [79] | 83 | I–IV | – | – | 0.022 | – | – | 0.003 | Log-rank test |
α-catenin | Nakanishi et al. [22] | 96 | I–III | 0.741 | 0.160–3.450 | 0.70 | – | – | – | Cox proportional hazards model |
Nair et al. [26] | 100 | I–III | – | – | >0.05 | – | – | – | Log-rank test | |
Setoyama et al. [80] | 205 | I–IV | 0.468 | 0.314–0.664 | <0.001 | – | – | – | Cox proportional hazards model | |
Lin et al. [81] | 62 | I–III | – | – | >0.05 | – | – | – | Log-rank test | |
β-catenin | Lv et al. [23] | 70 | I–IV | 0.034 | 0.009–0.144 | 0.002 | – | – | – | Cox proportional hazards model |
Nair et al. [26] | 100 | I–III | – | – | >0.05 | – | – | – | Log-rank test | |
Chang et al. [62] | 118 | I–IV | – | – | >0.05 | – | – | – | Log-rank test | |
Lin et al. [81] | 62 | I–III | – | – | >0.05 | – | – | – | Log-rank test | |
Situ et al. [82] | 227 | II | 1.642 | 1.159–2.327 | 0.005 | – | – | – | Cox proportional hazards model | |
Hsu et al. [83] | 68 | I–V | 0.433 | 0.244–0.765 | 0.004 (membrane) | – | – | – | Cox proportional hazards model | |
– | – | 0.821 (cytoplasm) | – | – | – | |||||
Zhao et al. [84] | 106 | I–IV | – | – | >0.05 | – | – | – | Log-rank test | |
Li et al. [85] | 128 | I–IV | – | – | 0.569 | – | – | 0.503 | Log-rank test | |
Deng et al. [86] | 100 | – | – | – | 0.872 | – | – | – | Log-rank test | |
Podoplanin | Tong et al. [16] | 56 | I–IV | 13.83 | 3.06–62.43 | 0.001 | – | – | – | Cox proportional hazards model |
Chao et al. [87] | 113 | II–IV | – | – | – | 1.951 | 1.231–3.090 | 0.004 | Cox proportional hazards model | |
Nakashima et al. [88] | 101 | I–IV | 2.16 | 1.05–4.65 | 0.036 | – | – | – | Cox proportional hazards model | |
Tanaka et al. [89] | 139 | I–III | 3.084 | 1.543–6.164 | 0.001 | – | – | – | Cox proportional hazards model | |
Rahadiani et al. [90] | 61 | I–IV | 1.926 | 1.085–3.421 | 0.0253 | 1.931 | 1.087–3.431 | 0.0249 | Cox proportional hazards model (univariate) | |
Fascin | Cao et al. [29] | 315 | I–IV | 1.749 | 1.065–2.873 | 0.027 | – | – | – | Cox proportional hazards model |
Hashimoto et al. [91] | 200 | I–IV | 1.79 | 1.15–2.77 | 0.0094 | – | – | – | Cox proportional hazards model | |
Zhao et al. [92] | 254 | I–IV | 1.604 | 1.145–2.248 | 0.006 | – | – | – | Cox proportional hazards model | |
Takikita et al. [93] | 257 | I–IV | 1.06 | 0.76–1.48 | 0.72 | – | – | – | Cox proportional hazards model | |