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Table 6 Prognostic markers involved in activating invasion and metastasis of ESCC as reported in original studies

From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Marker References Sample size Clinical stage OS DFS Analytic methods
HR 95% CI P value HR 95% CI P value
E-cadherin Ozawa et al. [79] 83 I–IV 0.022 0.003 Log-rank test
α-catenin Nakanishi et al. [22] 96 I–III 0.741 0.160–3.450 0.70 Cox proportional hazards model
Nair et al. [26] 100 I–III >0.05 Log-rank test
Setoyama et al. [80] 205 I–IV 0.468 0.314–0.664 <0.001 Cox proportional hazards model
Lin et al. [81] 62 I–III >0.05 Log-rank test
β-catenin Lv et al. [23] 70 I–IV 0.034 0.009–0.144 0.002 Cox proportional hazards model
Nair et al. [26] 100 I–III >0.05 Log-rank test
Chang et al. [62] 118 I–IV >0.05 Log-rank test
Lin et al. [81] 62 I–III >0.05 Log-rank test
Situ et al. [82] 227 II 1.642 1.159–2.327 0.005 Cox proportional hazards model
Hsu et al. [83] 68 I–V 0.433 0.244–0.765 0.004 (membrane) Cox proportional hazards model
0.821 (cytoplasm)
Zhao et al. [84] 106 I–IV >0.05 Log-rank test
Li et al. [85] 128 I–IV 0.569 0.503 Log-rank test
Deng et al. [86] 100 0.872 Log-rank test
Podoplanin Tong et al. [16] 56 I–IV 13.83 3.06–62.43 0.001 Cox proportional hazards model
Chao et al. [87] 113 II–IV 1.951 1.231–3.090 0.004 Cox proportional hazards model
Nakashima et al. [88] 101 I–IV 2.16 1.05–4.65 0.036 Cox proportional hazards model
Tanaka et al. [89] 139 I–III 3.084 1.543–6.164 0.001 Cox proportional hazards model
Rahadiani et al. [90] 61 I–IV 1.926 1.085–3.421 0.0253 1.931 1.087–3.431 0.0249 Cox proportional hazards model (univariate)
Fascin Cao et al. [29] 315 I–IV 1.749 1.065–2.873 0.027 Cox proportional hazards model
Hashimoto et al. [91] 200 I–IV 1.79 1.15–2.77 0.0094 Cox proportional hazards model
Zhao et al. [92] 254 I–IV 1.604 1.145–2.248 0.006 Cox proportional hazards model
Takikita et al. [93] 257 I–IV 1.06 0.76–1.48 0.72 Cox proportional hazards model
  1. No original studies on the prognostic significance of metastasis-associated protein 1 (MTA1) in ESCC were reported after the meta-analyses. Therefore, MTA1 is not listed
  2. ESCC esophageal squamous cell carcinoma; OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval, no data