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Table 3 Associations among PD-L1, PD-L2, PD-1 expression, and CD8(+) T-cell density in primary tumors from patients with gastric adenocarcinoma

From: Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma

Variable

PD-L1 expression [cases (%)]

PD-L2 expression [cases (%)]

Negative

Positive

P

Negative

Positive

P

PD-L2 expression

  

0.043

   

 Negative

57 (47.9)

28 (23.5)

    

 Positive

16 (13.4)

18 (15.1)

    

Density of CD8(+) T cells

  

0.022

  

0.004

 Low

22 (18.5)

24 (20.2)

 

26 (21.8)

20 (16.8)

 

 High

51 (42.9)

22 (18.5)

 

59 (49.6)

14 (11.8)

 

PD-1 expression on CD8(+) T cells

  

0.162

  

0.951

 Negative

49 (41.2)

25 (21.0)

 

53 (44.5)

21 (17.6)

 

 Positive

24 (20.2)

21 (17.6)

 

32 (26.9)

13 (10.9)