Table 1 Characteristics of 1860 patients with NSCLC according to smoking status
From: Proportion and clinical features of never-smokers with non-small cell lung cancer
Variable | Never-smokers [cases (%)] | Ever-smokers [cases (%)] | P |
|---|---|---|---|
Total | 707 (38.0) | 1153 (62.0) | |
Sex | <0.001 | ||
Men | 115 (16.3) | 1088 (94.4) | |
Women | 592 (83.7) | 65 (5.6) | |
Histologic subtype | <0.001 | ||
Adenocarcinoma | 635 (89.8) | 518 (44.9) | |
Squamous cell carcinoma | 25 (3.5) | 483 (41.9) | |
Others | 47 (6.7) | 152 (13.2) | |
ECOG PS | <0.001 | ||
0 | 379 (53.6) | 427 (37.0) | |
1 | 269 (38.1) | 558 (48.4) | |
2 | 43 (6.1) | 131 (11.4) | |
3 | 15 (2.1) | 31 (2.7) | |
4 | 1 (0.1) | 6 (0.5) | |
Symptoms at diagnosis | <0.001 | ||
Asymptomatic | 417 (59.0) | 487 (42.2) | |
Symptomatic | 290 (41.0) | 666 (57.8) | |
Driver mutations | |||
EGFR mutations (n = 1284) | 353 (57.8) | 164 (24.4) | <0.001 |
KRAS mutations (n = 1089) | 29 (5.8) | 57 (9.6) | 0.021 |
ALK rearrangements (n = 1288) | 47 (7.8) | 19 (2.8) | <0.001 |
Stage | <0.001 | ||
I | 261 (36.9) | 295 (25.6) | |
II | 54 (7.6) | 153 (13.3) | |
III | 115 (16.3) | 293 (25.4) | |
IV | 277 (39.2) | 412 (35.7) | |
Treatment | <0.001 | ||
Antitumor | 654 (92.5) | 983 (85.3) | |
Supportive/unknown | 53 (7.5) | 170 (14.7) |