Mutation genotype
|
Mutation type
|
Exon
|
Codon change
|
Amino acid change
|
Case ID/Cell line
|
---|
Colorectal cancer tissues
| |
CDS 21C→Ga
|
Nonsense
|
Exon 2
|
TAC→TAG
b
|
Y7stop
|
C56
|
chr2:53810098 G→C
|
Splice-site
|
Exon 3/Intron
|
–
|
–
|
C53
|
CDS 404G→R
|
Missense
|
Exon 4
|
GGA→GAA
|
G135E
|
S78, S64
|
CDS 1084C→Y
|
Missense
|
Exon 8
|
CGC→TGC
|
R362C
|
S35
|
CDS 1016A→W
|
Missense
|
Exon 8
|
AAA→ATA
|
K339I
|
S12, S61, S64
|
Colorectal cancer cell lines
| |
CDS 471A→T
|
Missense
|
Exon 5
|
GAA→GAT
|
E157D
|
HCT116
|
CDS 471A→W
|
Missense
|
Exon 5
|
GAA→GAT
|
E157D
|
HT-29
|
CDS 24G→R
|
Synonymous
|
Exon 2
|
GCG→GCA
|
Non
|
DLD-1
|
CDS 25G→K
|
Missense
|
Exon 2
|
GAC→TAC
|
D9Y
|
DLD-1
|
CDS 154T→Y
|
Missense
|
Exon 2
|
TAT→CAT
|
Y52H
|
DLD-1
|
CDS 922G→R
|
Missensee
|
Exon 7
|
GCC→ACC
|
A308T
|
DLD-1
|
- ASB3, ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein 3
- The nucleotides in bold indicate the one mutated
-
a
CDS coding domain sequence; A, T, C, G, four types of nucleotides; R = A/G; Y = C/T; W = A/T; K = G/T
-
bamino acid codon