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Table 1 The list of 150 pro-metastatic genes with clinical relevance and key references

From: For robust big data analyses: a collection of 150 important pro-metastatic genes

Number Gene name Clinical relevance validation (P value of overall survival analysis) Reference
ccRCC cohort HCC cohort
1 ADAM9 NS 0.001 [10]
2 ADORA2B 0.006 NS [11]
3 AGR2 <0.001 NS [12]
4 AKT1 NS NS [13]
5 ANXA1 NS NS [14]
6 APOBEC3G 0.045 NS [15]
7 ATF4 0.001 0.031 [16]
8 AXL 0.005 NS [17]
9 BACH1 NS NS [18]
10 BCL2L1 NS NS [19]
11 BCL3 <0.001 NS [20]
12 BIRC5 <0.001 <0.001 [21]
13 BSG NS 0.004 [22]
14 C5AR1 NS NS [23]
15 CAV1 NS NS [24]
16 CCL2 NS NS [25]
17 CCR7 NS 0.002 [26]
18 CD24 NS NS [27]
19 CD44 0.016 NS [28]
20 CDCP1 NS NS [29]
21 CEACAM6 0.004 NS [30]
22 CEBPD 0.022 NS [31]
23 CENPF <0.001 0.008 [32]
24 CHD1L <0.001 0.007 [33]
25 CHI3L1 NS NS [34]
26 CLDN9 0.039 NS [35]
27 COL6A1 <0.001 NS [36]
28 COMP 0.040 NS [37]
29 CSNK2A2 NS NS [38]
30 CTSB NS NS [38]
31 CTSZ <0.001 NS [39]
32 CXCL1 <0.001 0.001 [40]
33 CXCL10 NS NS [41]
34 CXCL8 0.002 <0.001 [42]
35 CXCR4 NS NS [43]
36 E2F1 0.001 0.005 [44]
37 EIF5A <0.001 NS [45]
38 ELF5 NS NS [46]
39 ENAH NS 0.012 [47]
40 ENPP2 NS NS [48]
41 ETV4 0.003 0.001 [49]
42 EZH2 <0.001 <0.001 [50]
43 FGFR1 NS NS [51]
44 FLOT2 NS NS [52]
45 FOSL1 <0.001 NS [53]
46 FOXC1 NS NS [54]
47 FOXM1 <0.001 0.009 [55]
48 FOXQ1 NS NS [56]
49 FZD2 <0.001 NS [57]
50 GABRA3 NS 0.004 [58]
51 GDF15 NS NS [59]
52 GHRL <0.001 NS [60]
53 GLI2 <0.001 NS [61]
54 GOLM1 NS 0.049 [62]
55 GRK3 NS NS [63]
56 HMGB1 NS NS [64]
57 HMMR 0.003 <0.001 [65]
58 HOXB13 <0.001 NS [66]
59 HOXB7 NS NS [67]
60 HOXB9 <0.001 NS [68]
61 ID1 NS NS [69]
62 IDO1 NS NS [70]
63 IGFBP2 NS NS [71]
64 IL32 NS NS [72]
65 IL5 NS NS [73]
66 IL6 <0.001 NS [74]
67 IP6K2 0.001 NS [75]
68 ITGA3 NS NS [76]
69 ITGA5 0.018 0.011 [77]
70 ITGBL1 NS NS [78]
71 KISS1R NS NS [79]
72 KLF8 NS NS [80]
73 L1CAM 0.007 NS [81]
74 LAMB3 0.001 NS [67]
75 LEF1 0.007 NS [82]
76 LGALS1 <0.001 0.048 [83]
77 LGALS3 NS NS [84]
78 LOX NS 0.047 [85]
79 LOXL2 0.033 NS [86]
80 MBD4 NS NS [87]
81 MCAM NS NS [88]
82 MET NS NS [89]
83 MMP1 0.030 0.002 [90]
84 MMP16 NS NS [91]
85 MMP9 0.001 0.009 [92]
86 MTA1 0.015 NS [93]
87 MTA2 0.001 NS [94]
88 MYB 0.031 0.021 [95]
89 NFATC2 NS NS [96]
90 NRP2 NS NS [97]
91 NTRK3 NS 0.044 [98]
92 PARP1 NS NS [99]
93 PCDH7 NS NS [100]
94 PDGFRB NS NS [101]
95 PDPN 0.034 NS [102]
96 PELP1 0.011 NS [103]
97 PHGDH NS NS [104]
98 PHIP NS NS [105]
99 PLAUR <0.001 NS [35]
100 PLOD2 0.004 0.008 [106]
101 POSTN NS NS [107]
102 PPIA 0.015 0.038 [108]
103 PRRX1 0.045 NS [109]
104 PRSS50 <0.001 NS [89]
105 PTGS2 0.040 NS [110]
106 PTTG1 <0.001 0.004 [111]
107 PXN 0.001 NS [112]
108 RAB22A 0.024 NS [113]
109 RAC1 NS NS [97]
110 RAF1 0.025 NS [23]
111 RHOC 0.030 NS [114]
112 ROR2 0.001 NS [115]
113 RRAS <0.001 NS [116]
114 RUNX3 NS 0.032 [117]
115 S100A4 NS NS [118]
116 S100P NS NS [119]
117 SEMA3E <0.001 NS [120]
118 SFRP2 0.020 NS [121]
119 SIX2 0.001 0.036 [122]
120 SNAI1 0.045 NS [123]
121 SNAI2 NS NS [124]
122 SOX12 <0.001 0.045 [125]
123 SOX4 NS 0.018 [126]
124 SPINK1 <0.001 NS [127]
125 SPON2 <0.001 NS [128]
126 SPP1 NS 0.000 [129]
127 SRC <0.001 0.037 [130]
128 SRGN NS NS [131]
129 SRPK1 NS NS [132]
130 TACSTD2 NS NS [133]
131 TDO2 0.020 NS [134]
132 TF <0.001 NS [135]
133 TGFB1 0.008 NS [73]
134 TGM2 0.003 NS [136]
135 TNC NS NS [137]
136 TNFSF10 NS NS [138]
137 TNK2 0.016 NS [139]
138 TP73 0.016 NS [140]
139 TPO 0.043 NS [141]
140 TRIM28 NS 0.00 [142]
141 TWIST1 0.002 NS [143]
142 UBE2 N NS NS [144]
143 VAV1 0.038 NS [145]
144 VEGFB NS NS [146]
145 VIM 0.014 NS [147]
146 WASF3 NS NS [148]
147 WNT5A 0.008 NS [149]
148 WSB1 <0.001 NS [150]
149 YBX1 0.038 <0.001 [151]
150 ZEB2 NS NS [152]
  1. NS not significant