Toxicity
|
Gene
|
SNP
|
Additive model
|
Dominant model
|
Recessive model
|
---|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
---|
Overall
|
MSH2
|
rs6544991
|
1.18 (0.77–1.79)
|
0.447
|
1.39 (0.76–2.55)
|
0.290
|
1.02 (0.44–2.33)
|
0.973
|
MSH3
|
rs6151627
|
1.20 (0.77–1.86)
|
0.419
|
1.49 (0.83–2.65)
|
0.181
|
0.77 (0.27–2.17)
|
0.618
|
|
rs6151670
|
1.14 (0.73–1.76)
|
0.572
|
1.37 (0.76–2.45)
|
0.293
|
0.75 (0.27–2.13)
|
0.593
|
|
rs7709909
|
1.21 (0.79–1.87)
|
0.380
|
1.51 (0.84–2.71)
|
0.163
|
0.83 (0.31–2.19)
|
0.703
|
MSH5
|
rs707939
|
0.45 (0.28–0.73)
|
0.001
|
0.42 (0.23–0.76)
|
0.004
|
0.27 (0.09–0.84)
|
0.023
|
|
rs805304
|
1.66 (1.04–2.65)
|
0.034
|
2.21 (1.19–4.09)
|
0.012
|
1.21 (0.44–3.34)
|
0.716
|
Hematologic
|
MSH2
|
rs6544991
|
1.01 (0.64–1.61)
|
0.957
|
0.97 (0.50–1.87)
|
0.919
|
1.12 (0.45–2.77)
|
0.805
|
MSH3
|
rs6151627
|
1.55 (0.96–2.50)
|
0.074
|
2.38 (1.23–4.60)
|
0.010
|
0.75 (0.23–2.44)
|
0.635
|
|
rs6151670
|
1.42 (0.88–2.29)
|
0.153
|
2.05 (1.07–3.93)
|
0.032
|
0.75 (0.23–2.43)
|
0.630
|
|
rs7709909
|
1.55 (0.97–2.49)
|
0.067
|
2.38 (1.23–4.64)
|
0.010
|
0.87 (0.30–2.58)
|
0.808
|
MSH5
|
rs707939
|
0.68 (0.41–1.12)
|
0.128
|
0.66 (0.35–1.28)
|
0.219
|
0.50 (0.16–1.54)
|
0.225
|
|
rs805304
|
1.37 (0.83–2.27)
|
0.223
|
1.99 (1.01–3.90)
|
0.047
|
0.60 (0.16–2.20)
|
0.436
|
Gastrointestinal
|
MSH2
|
rs6544991
|
1.56 (0.90–2.69)
|
0.113
|
2.98 (1.20–7.40)
|
0.019
|
0.88 (0.28–2.76)
|
0.827
|
MSH3
|
rs6151627
|
0.63 (0.33–1.20)
|
0.161
|
0.54 (0.24–1.19)
|
0.128
|
0.66 (0.14–3.02)
|
0.592
|
|
rs6151670
|
0.67 (0.35–1.27)
|
0.220
|
0.59 (0.27–1.32)
|
0.199
|
0.64 (0.14–2.94)
|
0.568
|
|
rs7709909
|
0.62 (0.33–1.18)
|
0.145
|
0.55 (0.25–1.20)
|
0.132
|
0.58 (0.13–2.63)
|
0.481
|
MSH5
|
rs707939
|
0.46 (0.24–0.88)
|
0.020
|
0.44 (0.20–0.96)
|
0.038
|
0.21 (0.03–1.65)
|
0.139
|
|
rs805304
|
1.64 (0.90–2.97)
|
0.105
|
1.86 (0.83–4.20)
|
0.133
|
1.85 (0.56–6.14)
|
0.314
|
-
OR odds ratio, 95% CI 95% confidence interval; other abbreviations as in Table 1