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Table 4 Univariate analysis of risk factors for CNS relapse in the R-CHOP set

From: New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma: a retrospective study

Variable Total (cases) CNS relapse [cases (%)] P
Stage    0.049
 I or II 217 4 (1.8)  
 III or IV 159 10 (6.3)  
IPI    0.017
 0–2 289 7 (2.4)  
 3–5 87 7 (8.0)  
Number of involved extranodal sitesa    0.004
 ≤1 303 7 (2.3)  
 >1 71 7 (9.9)  
Bone marrow involvement    0.004
 No 360 11 (3.1)  
 Yes 16 3 (18.8)  
Bone involvement    0.001
 No 335 9 (2.7)  
 Yes 41 5 (12.2)  
Renal involvement    <0.001
 No 360 10 (2.8)  
 Yes 16 4 (25.0)  
Testicular involvement    0.043
 No 368 13 (3.5)  
 Yes 8 1 (12.5)  
LC    0.081
 <1.3 × 109 132 12 (9.1)  
 ≥1.3 × 109 244 2 (0.8)  
ALP    0.019
 ≤110 U/L 341 10 (2.9)  
 >110 U/L 35 4 (11.4)  
HDLb    0.028
 <0.78 mmol/L 64 10 (15.6)  
 ≥0.78 mmol/L 307 4 (1.3)  
IT chemotherapy prophylaxisc    0.083
 No 329 10 (3.0)  
 Yes 44 4 (9.1)  
  1. Abbreviations as in Table 1
  2. aThe data of two patients were missing
  3. bThe data of five patients were missing
  4. cThe data of three patients were missing