New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma: a retrospective study

Table 2 Univariate analysis of risk factors for CNS relapse in the entire cohort

Variable	Total (cases)	CNS relapse [cases (%)]	P
Stage			0.022
I or II	294	9 (3.1)
III or IV	217	16 (7.4)
IPI			0.026
0–2	402	16 (4.0)
3–5	109	9 (8.3)
Number of involved extranodal sites^a			0.001
≤1	415	15 (3.6)
>1	94	10 (10.6)
Bone marrow involvement			0.043
No	493	22 (4.5)
Yes	18	3 (16.7)
Bone involvement			0.001
No	455	18 (4.0)
Yes	56	7 (12.5)
Renal involvement			<0.001
No	490	19 (3.9)
Yes	21	6 (28.6)
WBC count^b			0.056
<4.0 × 10⁹/L	32	4 (12.5)
≥4.0 × 10⁹/L	478	21 (4.4)
LC^c			0.027
<1.3 × 10⁹/L	169	12 (7.1)
≥1.3 × 10⁹/L	341	13 (3.8)
PLT^d			0.063
<100 × 10⁹/L	21	2 (9.5)
≥100 × 10⁹/L	489	23 (4.7)
LDH^e			0.015
≤1 ULN^f	294	9 (3.1)
>1 ULN	214	16 (7.5)
ALP^g			0.001
≤110 U/L	460	18 (3.9)
>110 U/L	50	7 (14.0)
ALB			0.005
<35 g/L	441	7 (1.6)
≥35 g/L	70	18 (25.7)
TP			0.063
< 60 g/L	56	7 (12.5)
≥60 g/L	455	18 (4.0)
HDL^h			0.014
< 0.78 mmol/L	94	10 (10.6)
≥0.78 mmol/L	409	14 (3.4)
Apo-A1ⁱ			0.030
<1.05 g/L	205	14 (6.8)
≥1.05 g/L	296	9 (3.0)
Rituximab treatment			0.045
Without	135	11 (8.1)
With	376	14 (3.7)
IT chemotherapy prophylaxis^j			0.053
No	446	19 (4.3)
Yes	62	6 (9.7)
CR with first-line therapy^k			0.036
No	157	14 (8.9)
Yes	349	11 (3.1)
TTC^l			0.003
≤108 days	261	7 (2.6)
>108 days	222	13 (5.9)

WBC white blood cell, LC lymphocyte count, PLT platelet count, TP total protein, HDL high-density lipoprotein, Apo-A1 apolipoprotein-A1, CR complete remission. Other abbreviations as in Table 1
^aThe data of two patients were missing
^bThe data of one patient were missing
^cThe data of one patient were missing
^dThe data of one patient were missing
^eThe data of three patients were missing
^fULN for LDH: 245 U/L
^gThe data of one patient were missing
^hThe data of eight patients, including one who developed in the CNS relapse, were missing
ⁱThe data of ten patients, including two who developed CNS relapse, were missing
^jThe data of three patients were missing
^kThe data of five patients were missing
^lThe data of 28 patients, including five patients who developed CNS relapse, were missing

ISSN: 2523-3548