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Table 2 Univariate analysis of risk factors for CNS relapse in the entire cohort

From: New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma: a retrospective study

Variable Total (cases) CNS relapse [cases (%)] P
Stage    0.022
 I or II 294 9 (3.1)  
 III or IV 217 16 (7.4)  
IPI    0.026
 0–2 402 16 (4.0)  
 3–5 109 9 (8.3)  
Number of involved extranodal sitesa    0.001
 ≤1 415 15 (3.6)  
 >1 94 10 (10.6)  
Bone marrow involvement    0.043
 No 493 22 (4.5)  
 Yes 18 3 (16.7)  
Bone involvement    0.001
 No 455 18 (4.0)  
 Yes 56 7 (12.5)  
Renal involvement    <0.001
 No 490 19 (3.9)  
 Yes 21 6 (28.6)  
WBC countb    0.056
 <4.0 × 109/L 32 4 (12.5)  
 ≥4.0 × 109/L 478 21 (4.4)  
LCc    0.027
 <1.3 × 109/L 169 12 (7.1)  
 ≥1.3 × 109/L 341 13 (3.8)  
PLTd    0.063
 <100 × 109/L 21 2 (9.5)  
 ≥100 × 109/L 489 23 (4.7)  
LDHe    0.015
 ≤1 ULNf 294 9 (3.1)  
 >1 ULN 214 16 (7.5)  
ALPg    0.001
 ≤110 U/L 460 18 (3.9)  
 >110 U/L 50 7 (14.0)  
ALB    0.005
 <35 g/L 441 7 (1.6)  
 ≥35 g/L 70 18 (25.7)  
TP    0.063
 < 60 g/L 56 7 (12.5)  
 ≥60 g/L 455 18 (4.0)  
HDLh    0.014
 < 0.78 mmol/L 94 10 (10.6)  
 ≥0.78 mmol/L 409 14 (3.4)  
Apo-A1i    0.030
 <1.05 g/L 205 14 (6.8)  
 ≥1.05 g/L 296 9 (3.0)  
Rituximab treatment    0.045
 Without 135 11 (8.1)  
 With 376 14 (3.7)  
IT chemotherapy prophylaxisj    0.053
 No 446 19 (4.3)  
 Yes 62 6 (9.7)  
CR with first-line therapyk    0.036
 No 157 14 (8.9)  
 Yes 349 11 (3.1)  
TTCl    0.003
 ≤108 days 261 7 (2.6)  
 >108 days 222 13 (5.9)  
  1. WBC white blood cell, LC lymphocyte count, PLT platelet count, TP total protein, HDL high-density lipoprotein, Apo-A1 apolipoprotein-A1, CR complete remission. Other abbreviations as in Table 1
  2. aThe data of two patients were missing
  3. bThe data of one patient were missing
  4. cThe data of one patient were missing
  5. dThe data of one patient were missing
  6. eThe data of three patients were missing
  7. fULN for LDH: 245 U/L
  8. gThe data of one patient were missing
  9. hThe data of eight patients, including one who developed in the CNS relapse, were missing
  10. iThe data of ten patients, including two who developed CNS relapse, were missing
  11. jThe data of three patients were missing
  12. kThe data of five patients were missing
  13. lThe data of 28 patients, including five patients who developed CNS relapse, were missing