Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study

Table 4 LOH profiles in 10 patients with SHC in the same liver

Case no.	Tumor nodule	LOH locus										Different LOH	Informative loci	Different LOH/informative loci (%)	Clonality diagnosis
Case no.	Tumor nodule	D4S402	D4S406	D17S831	D16S505	D17S938	D8S277	D16S514	D8S520	D8S258	D8S264	Different LOH	Informative loci	Different LOH/informative loci (%)	Clonality diagnosis
1	T1	○	○	○	○	NI	○	●	●	●	○	3	8	37.5	MO
	T2	●	●	○	○	●	○	F	●	○	○
2	T1	●	NI	○	○	●	●	●	○	NI	○	3	8	37.5	MO
	T2	○	NI	○	○	○	●	●	○	F	●
3	T1	○	○	●	○	F	●	●	●	●	○	3	9	33.3	MO
	T2	○	○	●	●	F	○	●	○	●	○
4	T1	○	●	●	○	○	○	○	●	●	F	3	8	37.5	MO
	T2	○	○	●	○	●	F	○	●	▲	○
5	T1	●	●	○	○	●	●	●	F	●	○	3	9	33.3	MO
	T2	●	●	○	●	●	○	●	F	●	●
6	T1	●	○	○	F	●	○	●	○	●	F	3	8	37.5	MO
	T2	●	○	●	F	●	●	○	○	●	NI
7	T1	●	○	○	●	●	F	●	F	○	○	3	8	37.5	MO
	T2	●	○	●	●	○	F	●	F	○	●
8	T1	○	○	NI	●	●	NI	▲	●	●	F	3	7	42.8	MO
	T2	●	○	NI	○	●	NI	●	●	●	NI
9	T1	○	○	●	○	F	●	●	●	●	○	3	9	33.3	MO
	T2	○	○	●	●	F	○	●	○	●	○
10	T1	●	○	●	○	○	○	●	F	○	○	3	8	37.5	MO
	T2	●	F	●	●	○	●	●	○	○	●

SHC separated hepatocellular carcinoma and intrahepatic cholangiocarcinoma, T1 HCC nodule of SHC, T2 ICC nodule of SHC, ● LOH, ▲ missing but not in the same band, ○ retain, NI non-informative, F not done, SO single clonal origin, MO multiple clonal origins

ISSN: 2523-3548