Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study

Table 3 LOH profiles in 16 patients with CHC

Case no.	Tumor component	LOH locus										Different LOH	Informative loci	Different LOH/informative loci (%)	Clonality diagnosis
Case no.	Tumor component	D4S402	D4S406	D17S831	D16S505	D17S938	D8S277	D16S514	D8S520	D8S258	D8S264	Different LOH	Informative loci	Different LOH/informative loci (%)	Clonality diagnosis
1	T1	○	○	○	●	NI	○	●	F	●	●	2	8	25.0	SO
	T2	○	●	○	●	F	○	●	●	○	●
2	T1	●	○	○	NI	●	●	●	○	F	○	2	7	28.5	SO
	T2	●	○	●	○	NI	●	●	●	F	○
3	T1	○	○	●	●	○	●	●	●	●	○	2	8	25.0	SO
	T2	F	F	●	●	○	○	●	○	●	○
4	T1	○	○	●	○	○	○	F	●	●	○	2	7	28.5	SO
	T2	NI	○	●	○	●	F	NI	●	○	○
5	T1	●	●	○	○	●	●	○	●	○	●	2	9	22.2	SO
	T2	F	●	○	●	●	▲	○	●	○	●
6	T1	NI	○	○	○	●	○	○	○	●	F	2	8	25.0	SO
	T2	○	○	●	○	●	●	○	○	●	○
7	T1	F	○	NI	●	●	○	●	○	○	○	2	7	28.5	SO
	T2	●	○	●	F	○	○	●	○	○	●
8	T1	●	○	○	●	●	F	○	●	○	○	2	8	25.0	SO
	T2	○	○	○	NI	●	○	○	●	●	○
9	T1	○	○	●	○	NI	●	○	●	●	○	2	9	22.2	SO
	T2	●	○	●	●	●	●	○	●	●	○
10	T1	●	○	F	●	●	○	●	○	○	●	2	8	25.0	SO
	T2	NI	○	●	●	○	○	●	●	○	●
11	T1	○	●	○	●	NI	○	○	F	●	●	2	8	25.0	SO
	T2	○	●	○	●	F	○	●	●	○	●
12	T1	●	○	○	○	●	●	●	○	F	●	2	9	22.2	SO
	T2	●	○	●	○	○	●	●	○	F	●
13	T1	○	○	●	F	○	●	●	●	●	○	2	9	22.2	SO
	T2	○	●	●	●	○	●	●	○	●	○
14	T1	○	○	●	○	▲	○	○	●	●	○	2	8	25.0	SO
	T2	○	○	F	○	●	○	○	●	○	NI
15	T1	●	●	○	○	NI	●	○	●	●	○	2	8	25.0	SO
	T2	○	●	○	●	●	F	○	●	●	○
16	T1	F	○	●	○	○	○	○	●	●	○	2	8	25.0	SO
	T2	○	○	●	○	●	NI	○	●	○	○

LOH loss of heterozygosity, CHC combined hepatocellular and cholangiocarcinoma, T1 HCC component of CHC, T2 ICC component of CHC, ● LOH, ▲ missing but not in the same band, ○ retain, NI non-informative, F not done, SO single clonal origin, MO multiple clonal origins

ISSN: 2523-3548