Case no.
|
Tumor component
|
LOH locus
|
Different LOH
|
Informative loci
|
Different LOH/informative loci (%)
|
Clonality diagnosis
|
---|
D4S402
|
D4S406
|
D17S831
|
D16S505
|
D17S938
|
D8S277
|
D16S514
|
D8S520
|
D8S258
|
D8S264
|
---|
1
|
T1
| ○ | ○ | ○ | ● |
NI
| ○ | ● |
F
| ● | ● |
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ● | ○ | ● |
F
| ○ | ● | ● | ○ | ● | | | | |
2
|
T1
| ● | ○ | ○ |
NI
| ● | ● | ● | ○ |
F
| ○ |
2
|
7
|
28.5
|
SO
|
|
T2
| ● | ○ | ● | ○ |
NI
| ● | ● | ● |
F
| ○ | | | | |
3
|
T1
| ○ | ○ | ● | ● | ○ | ● | ● | ● | ● | ○ |
2
|
8
|
25.0
|
SO
|
|
T2
|
F
|
F
| ● | ● | ○ | ○ | ● | ○ | ● | ○ | | | | |
4
|
T1
| ○ | ○ | ● | ○ | ○ | ○ |
F
| ● | ● | ○ |
2
|
7
|
28.5
|
SO
|
|
T2
|
NI
| ○ | ● | ○ | ● |
F
|
NI
| ● | ○ | ○ | | | | |
5
|
T1
| ● | ● | ○ | ○ | ● | ● | ○ | ● | ○ | ● |
2
|
9
|
22.2
|
SO
|
|
T2
|
F
| ● | ○ | ● | ● |
▲
| ○ | ● | ○ | ● | | | | |
6
|
T1
|
NI
| ○ | ○ | ○ | ● | ○ | ○ | ○ | ● |
F
|
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ○ | ● | ○ | ● | ● | ○ | ○ | ● | ○ | | | | |
7
|
T1
|
F
| ○ |
NI
| ● | ● | ○ | ● | ○ | ○ | ○ |
2
|
7
|
28.5
|
SO
|
|
T2
| ● | ○ | ● |
F
| ○ | ○ | ● | ○ | ○ | ● | | | | |
8
|
T1
| ● | ○ | ○ | ● | ● |
F
| ○ | ● | ○ | ○ |
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ○ | ○ |
NI
| ● | ○ | ○ | ● | ● | ○ | | | | |
9
|
T1
| ○ | ○ | ● | ○ |
NI
| ● | ○ | ● | ● | ○ |
2
|
9
|
22.2
|
SO
|
|
T2
| ● | ○ | ● | ● | ● | ● | ○ | ● | ● | ○ | | | | |
10
|
T1
| ● | ○ |
F
| ● | ● | ○ | ● | ○ | ○ | ● |
2
|
8
|
25.0
|
SO
|
|
T2
|
NI
| ○ | ● | ● | ○ | ○ | ● | ● | ○ | ● | | | | |
11
|
T1
| ○ | ● | ○ | ● |
NI
| ○ | ○ |
F
| ● | ● |
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ● | ○ | ● |
F
| ○ | ● | ● | ○ | ● | | | | |
12
|
T1
| ● | ○ | ○ | ○ | ● | ● | ● | ○ |
F
| ● |
2
|
9
|
22.2
|
SO
|
|
T2
| ● | ○ | ● | ○ | ○ | ● | ● | ○ |
F
| ● | | | | |
13
|
T1
| ○ | ○ | ● |
F
| ○ | ● | ● | ● | ● | ○ |
2
|
9
|
22.2
|
SO
|
|
T2
| ○ | ● | ● | ● | ○ | ● | ● | ○ | ● | ○ | | | | |
14
|
T1
| ○ | ○ | ● | ○ |
▲
| ○ | ○ | ● | ● | ○ |
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ○ |
F
| ○ | ● | ○ | ○ | ● | ○ |
NI
| | | | |
15
|
T1
| ● | ● | ○ | ○ |
NI
| ● | ○ | ● | ● | ○ |
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ● | ○ | ● | ● |
F
| ○ | ● | ● | ○ | | | | |
16
|
T1
|
F
| ○ | ● | ○ | ○ | ○ | ○ | ● | ● | ○ |
2
|
8
|
25.0
|
SO
|
|
T2
| ○ | ○ | ● | ○ | ● |
NI
| ○ | ● | ○ | ○ | | | | |
-
LOH loss of heterozygosity, CHC combined hepatocellular and cholangiocarcinoma, T1 HCC component of CHC, T2 ICC component of CHC, ● LOH, ▲ missing but not in the same band, ○ retain, NI non-informative, F not done, SO single clonal origin, MO multiple clonal origins