|
Gene SNP
|
Genotype
|
Response
|
|---|
|
Sensitive [cases (%)]
|
Resistant [cases (%)]
|
Additive model
|
Dominant model
|
Recessive model
|
|---|
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
|---|
|
Total
| |
115
|
280
| | | | | | |
|
OCT2
|
|
rs316003
|
CC
|
5 (4.3)
|
13 (4.6)
|
1.00 (0.68–1.47)
|
0.992
|
1.01 (0.63–1.60)
|
0.984
|
0.96 (0.33–2.81)
|
0.939
|
|
CT
|
38 (33.0)
|
93 (33.2)
|
|
TT
|
65 (56.5)
|
166 (59.3)
|
|
rs316019
|
TT
|
2 (1.7)
|
7 (2.5)
|
1.08 (0.69–1.69)
|
0.741
|
1.05 (0.63–1.75)
|
0.840
|
1.51 (0.30–7.51)
|
0.616
|
|
GT
|
27 (23.5)
|
68 (24.3)
|
|
GG
|
79 (68.7)
|
197 (70.4)
|
|
ABCB1
| |
|
rs1045642
|
TT
|
10 (8.7)
|
45 (16.1)
|
1.18 (0.85–1.65)
|
0.323
|
1.05 (0.66–1.66)
|
0.834
|
1.84 (0.89–3.83)
|
0.102
|
|
CT
|
57 (49.6)
|
129 (46.1)
|
|
CC
|
45 (39.1)
|
103 (36.8)
|
|
ABCC2
|
|
rs717620
|
AA
|
3 (2.6)
|
9 (3.2)
|
0.64 (0.43–0.96)
|
0.031
|
0.54 (0.34–0.86)
|
0.010
|
1.22 (0.32–4.68)
|
0.772
|
|
AG
|
46 (40.0)
|
72 (25.7)
|
|
GG
|
62 (53.9)
|
186 (66.4)
|
|
rs2273697
|
AA
|
1 (0.9)
|
1 (0.4)
|
1.29 (0.73–2.28)
|
0.391
|
1.35 (0.74–2.47)
|
0.328
|
0.59 (0.04–9.55)
|
0.709
|
|
AG
|
16 (13.9)
|
52 (18.6)
|
|
GG
|
97 (84.3)
|
227 (81.1)
|
|
rs3740066
|
AA
|
4 (3.5)
|
10 (3.6)
|
0.80 (0.54–1.19)
|
0.271
|
0.72 (0.45–1.14)
|
0.162
|
1.18 (0.36–3.90)
|
0.790
|
|
AG
|
42 (36.5)
|
81 (28.9)
|
|
GG
|
65 (56.5)
|
181 (64.6)
|
|
MATE1
|
|
rs2289669
|
AA
|
20 (17.4)
|
65 (23.2)
|
1.30 (0.93–1.81)
|
0.126
|
1.32 (0.79–2.21)
|
0.293
|
1.51 (0.86–2.66)
|
0.155
|
|
AG
|
58 (50.4)
|
140 (50.0)
|
|
GG
|
30 (26.1)
|
62 (22.1)
|
-
OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1
