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Table 4 Associations of seven SNPs with platinum-based chemotherapy response in 395 NSCLC patients

From: Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Gene SNP Genotype Response
Sensitive [cases (%)] Resistant [cases (%)] Additive model Dominant model Recessive model
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total   115 280       
OCT2
 rs316003 CC 5 (4.3) 13 (4.6) 1.00 (0.68–1.47) 0.992 1.01 (0.63–1.60) 0.984 0.96 (0.33–2.81) 0.939
CT 38 (33.0) 93 (33.2)
TT 65 (56.5) 166 (59.3)
 rs316019 TT 2 (1.7) 7 (2.5) 1.08 (0.69–1.69) 0.741 1.05 (0.63–1.75) 0.840 1.51 (0.30–7.51) 0.616
GT 27 (23.5) 68 (24.3)
GG 79 (68.7) 197 (70.4)
ABCB1  
 rs1045642 TT 10 (8.7) 45 (16.1) 1.18 (0.85–1.65) 0.323 1.05 (0.66–1.66) 0.834 1.84 (0.89–3.83) 0.102
CT 57 (49.6) 129 (46.1)
CC 45 (39.1) 103 (36.8)
ABCC2
 rs717620 AA 3 (2.6) 9 (3.2) 0.64 (0.43–0.96) 0.031 0.54 (0.34–0.86) 0.010 1.22 (0.32–4.68) 0.772
AG 46 (40.0) 72 (25.7)
GG 62 (53.9) 186 (66.4)
 rs2273697 AA 1 (0.9) 1 (0.4) 1.29 (0.73–2.28) 0.391 1.35 (0.74–2.47) 0.328 0.59 (0.04–9.55) 0.709
AG 16 (13.9) 52 (18.6)
GG 97 (84.3) 227 (81.1)
 rs3740066 AA 4 (3.5) 10 (3.6) 0.80 (0.54–1.19) 0.271 0.72 (0.45–1.14) 0.162 1.18 (0.36–3.90) 0.790
AG 42 (36.5) 81 (28.9)
GG 65 (56.5) 181 (64.6)
MATE1
 rs2289669 AA 20 (17.4) 65 (23.2) 1.30 (0.93–1.81) 0.126 1.32 (0.79–2.21) 0.293 1.51 (0.86–2.66) 0.155
AG 58 (50.4) 140 (50.0)
GG 30 (26.1) 62 (22.1)
  1. OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1