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Table 3 Associations of seven SNPs with platinum-based chemotherapy toxicity in the 403 NSCLC patients

From: Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Gene SNP

Genotype

Hepatotoxicity

Grade 1–2 [cases (%)]

Grade 3–4 [cases (%)]

Additive model

Dominant model

Recessive model

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Total

 

348

55

      

OCT2

 rs316003

CC

18 (5.2)

1 (1.8)

0.61 (0.34–1.08)

0.089

0.59 (0.31–1.12)

0.109

0.37 (0.05–2.83)

0.336

CT

120 (34.5)

14 (25.5)

      

TT

298 (85.6)

37 (67.3)

      

 rs316019

TT

9 (2.6)

0 (0.0)

0.42 (0.20–0.90)

0.026

0.42 (0.19–0.93)

0.033

0.00

0.998

GT

87 (25.0)

8 (14.5)

      

GG

239 (68.7)

45 (81.8)

      

ABCB1

 rs1045642

TT

51 (14.7)

6 (10.9)

0.81 (0.52–1.26)

0.354

0.75 (0.42–1.35)

0.337

0.81 (0.32–2.01)

0.643

CT

165 (47.4)

24 (43.6)

      

CC

126 (36.2)

24 (43.6)

      

ABCC2

 rs717620

AA

10 (2.9)

2 (3.6)

0.93 (0.54–1.59)

0.782

0.89 (0.48–1.66)

0.712

1.11 (0.23–5.44)

0.895

AG

104 (29.9)

15 (27.3)

      

GG

216 (62.1)

38 (69.1)

      

 rs2273697

AA

2 (0.6)

0 (0.0)

1.15 (0.58–2.28)

0.682

1.20 (0.59–2.44)

0.608

0.00

0.999

AG

60 (17.2)

12 (21.8)

      

GG

285 (81.9)

43 (78.2)

      

 rs3740066

AA

12 (3.4)

2 (3.6)

0.69 (0.38–1.23)

0.206

0.60 (0.31–1.17)

0.134

1.04 (0.22–4.92)

0.958

AG

113 (32.5)

11 (20.0)

      

GG

213 (61.2)

39 (70.9)

      

MATE1

 rs2289669

AA

79 (22.7)

10 (18.2)

0.86 (0.56–1.33)

0.500

0.92 (0.46–1.82)

0.804

0.73 (0.35–1.53)

0.402

AG

175 (50.3)

30 (54.5)

      

GG

80 (23.0)

13 (23.6)

      

Gene SNP

Genotype

Gastrointestinal toxicity

Grade 1–2 [cases (%)]

Grade 3–4 [cases (%)]c

Additive model

Dominant model

Recessive model

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Total

 

368

35

      

OCT2

 rs316003

CC

17 (4.6)

2 (5.7)

1.27 (0.72–2.25)

0.412

1.40 (0.69–2.85)

0.357

1.14 (0.25–5.23)

0.870

CT

120 (32.6)

14 (40.0)

      

TT

217 (59.0)

18 (51.4)

      

 rs316019

TT

8 (2.2)

1 (2.9)

0.49 (0.20–1.17)

0.106

0.39 (0.15–1.05)

0.062

1.16 (0.14–9.74)

0.893

GT

91 (24.7)

4 (11.4)

      

GG

254 (69.0)

30 (85.7)

      

ABCB1

 rs1045642

TT

52 (14.1)

5 (14.3)

0.71 (0.41–1.22)

0.217

0.54 (0.26–1.10)

0.091

0.96 (0.35–2.63)

0.941

CT

177 (48.1)

12 (34.3)

      

CC

133 (36.1)

17 (48.6)

      

ABCC2

 rs717620

AA

11 (3.0)

1 (2.9)

0.79 (0.38–1.61)

0.510

0.73 (0.32–1.63)

0.438

1.09 (0.13–8.81)

0.939

AG

111 (30.2)

8 (22.9)

      

GG

231 (62.8)

23 (65.7)

      

 rs2273697

AA

2 (0.5)

0 (0.0)

1.94 (0.93–4.04)

0.078

2.10 (0.97–4.53)

0.060

0.00

0.999

AG

61 (16.6)

11 (31.4)

      

GG

304 (82.6)

24 (68.6)

      

 rs3740066

AA

12 (3.3)

2 (5.7)

0.91 (0.47–1.79)

0.795

0.76 (0.35–1.67)

0.500

2.25 (0.47–10.75)

0.309

AG

116 (31.5)

8 (22.9)

      

GG

229 (62.2)

23 (65.7)

      

MATE1

 rs2289669

AA

79 (21.5)

10 (28.6)

1.35 (0.80–2.28)

0.254

1.55 (0.62–3.89)

0.350

1.44 (0.66–3.16)

0.363

AG

187 (50.8)

18 (51.4)

      

GG

87 (23.6)

6 (17.1)

      

Gene SNP

Genotype

Hematological toxicity

Grade 1–2 [cases (%)]

Grade 3–4 [cases (%)]

Additive model

Dominant model

Recessive model

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Total

 

308

95

      

OCT2

 rs316003

CC

17 (5.5)

2 (2.1)

0.75 (0.49–1.15)

0.190

0.78 (0.47–1.28)

0.324

0.37 (0.08–1.67)

0.196

CT

103 (33.4)

31 (32.6)

      

TT

176 (57.1)

59 (62.1)

      

 rs316019

TT

9 (2.9)

0 (0.0)

0.58 (0.34–0.97)

0.039

0.61 (0.34–1.07)

0.085

0.00

0.998

GT

75 (24.4)

20 (21.1)

      

GG

209 (67.9)

75 (78.9)

      

ABCB1

 rs1045642

TT

44 (14.3)

13 (13.7)

0.92 (0.65–1.31)

0.648

0.87 (0.53–1.41)

0.560

0.97 (0.49–1.93)

0.936

CT

147 (47.7)

42 (44.2)

      

CC

111 (36.0)

39 (41.1)

      

ABCC2

         

 rs717620

AA

8 (2.6)

4 (4.2)

1.15 (0.74–1.78)

0.546

1.09 (0.66–1.81)

0.736

1.88 (0.53–6.72)

0.330

AG

91 (29.5)

28 (29.5)

      

GG

196 (63.6)

58 (61.1)

      

 rs2273697

AA

1 (0.3)

1 (1.1)

1.13 (0.64–1.98)

0.679

1.10 (0.60–1.99)

0.759

2.46 (0.15–40.00)

0.528

AG

54 (17.5)

18 (18.9)

      

GG

252 (81.8)

76 (80.0)

      

 rs3740066

AA

12 (3.9)

2 (2.1)

0.89 (0.58–1.38)

0.600

0.94 (0.57–1.55)

0.806

0.49 (0.11–2.27)

0.361

AG

94 (30.5)

30 (31.6)

      

GG

192 (62.3)

60 (63.2)

      

MATE1

 rs2289669

AA

58 (18.8)

31 (32.6)

1.30 (0.92–1.83)

0.141

0.99 (0.57–1.72)

0.973

1.92 (1.13–3.25)

0.016

AG

164 (53.2)

41 (43.2)

      

GG

70 (22.7)

23 (24.2)

      

Gene SNP

Genotype

Overall toxicity

Grade 1–2 [cases (%)]

Grade 3–4 [cases (%)]

Additive model

Dominant model

Recessive model

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Total

 

268

135

      

OCT2

 rs316003

CC

14 (5.2)

5 (3.7)

0.85 (0.59–1.23)

0.400

0.86 (0.56–1.33)

0.502

0.66 (0.23–1.90)

0.446

CT

91 (34.0)

43 (31.9)

      

TT

154 (57.5)

81 (60.0)

      

 rs316019

TT

8 (3.0)

1 (0.7)

0.59 (0.37–0.93)

0.024

0.59 (0.36–0.98)

0.041

0.21 (0.03–1.75)

0.150

GT

68 (25.4)

27 (20.0)

      

GG

179 (66.8)

105 (77.8)

      

ABCB1

 rs1045642

TT

39 (14.6)

18 (13.3)

0.91 (0.67–1.24)

0.539

0.89 (0.58–1.38)

0.604

0.86 (0.47–1.58)

0.632

CT

126 (47.0)

63 (46.7)

      

CC

98 (36.6)

52 (38.5)

      

ABCC2

 rs717620

AA

7 (2.6)

5 (3.7)

1.04 (0.70–1.54)

0.838

1.00 (0.63–1.56)

0.985

1.52 (0.47–4.91)

0.489

AG

80 (29.9)

39 (28.9)

      

GG

169 (63.1)

85 (63.0)

      

 rs2273697

AA

1 (0.4)

1 (0.7)

1.49 (0.90–2.54)

0.118

1.50 (0.89–2.53)

0.128

2.30 (0.14–37.24)

0.557

AG

42 (15.7)

30 (22.2)

      

GG

224 (83.6)

104 (77.0)

      

 rs3740066

AA

11 (4.1)

3 (2.2)

0.86 (0.58–1.27)

0.446

0.88 (0.56–1.37)

0.573

0.58 (0.16–2.12)

0.409

AG

83 (31.0)

41 (30.4)

      

GG

165 (61.6)

87 (64.4)

      

MATE1

 rs2289669

AA

50 (18.7)

39 (28.9)

1.30 (1.00–1.86)

0.052

1.28 (0.77–2.13)

0.335

1.73 (1.06–2.82)

0.029

AG

140 (52.2)

65 (48.1)

      

GG

65 (24.3)

28 (20.7)

      
  1. OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1
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