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Table 3 Associations of seven SNPs with platinum-based chemotherapy toxicity in the 403 NSCLC patients

From: Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Gene SNP Genotype Hepatotoxicity
Grade 1–2 [cases (%)] Grade 3–4 [cases (%)] Additive model Dominant model Recessive model
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total   348 55       
OCT2
 rs316003 CC 18 (5.2) 1 (1.8) 0.61 (0.34–1.08) 0.089 0.59 (0.31–1.12) 0.109 0.37 (0.05–2.83) 0.336
CT 120 (34.5) 14 (25.5)       
TT 298 (85.6) 37 (67.3)       
 rs316019 TT 9 (2.6) 0 (0.0) 0.42 (0.20–0.90) 0.026 0.42 (0.19–0.93) 0.033 0.00 0.998
GT 87 (25.0) 8 (14.5)       
GG 239 (68.7) 45 (81.8)       
ABCB1
 rs1045642 TT 51 (14.7) 6 (10.9) 0.81 (0.52–1.26) 0.354 0.75 (0.42–1.35) 0.337 0.81 (0.32–2.01) 0.643
CT 165 (47.4) 24 (43.6)       
CC 126 (36.2) 24 (43.6)       
ABCC2
 rs717620 AA 10 (2.9) 2 (3.6) 0.93 (0.54–1.59) 0.782 0.89 (0.48–1.66) 0.712 1.11 (0.23–5.44) 0.895
AG 104 (29.9) 15 (27.3)       
GG 216 (62.1) 38 (69.1)       
 rs2273697 AA 2 (0.6) 0 (0.0) 1.15 (0.58–2.28) 0.682 1.20 (0.59–2.44) 0.608 0.00 0.999
AG 60 (17.2) 12 (21.8)       
GG 285 (81.9) 43 (78.2)       
 rs3740066 AA 12 (3.4) 2 (3.6) 0.69 (0.38–1.23) 0.206 0.60 (0.31–1.17) 0.134 1.04 (0.22–4.92) 0.958
AG 113 (32.5) 11 (20.0)       
GG 213 (61.2) 39 (70.9)       
MATE1
 rs2289669 AA 79 (22.7) 10 (18.2) 0.86 (0.56–1.33) 0.500 0.92 (0.46–1.82) 0.804 0.73 (0.35–1.53) 0.402
AG 175 (50.3) 30 (54.5)       
GG 80 (23.0) 13 (23.6)       
  1. OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1
Gene SNP Genotype Gastrointestinal toxicity
Grade 1–2 [cases (%)] Grade 3–4 [cases (%)]c Additive model Dominant model Recessive model
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total   368 35       
OCT2
 rs316003 CC 17 (4.6) 2 (5.7) 1.27 (0.72–2.25) 0.412 1.40 (0.69–2.85) 0.357 1.14 (0.25–5.23) 0.870
CT 120 (32.6) 14 (40.0)       
TT 217 (59.0) 18 (51.4)       
 rs316019 TT 8 (2.2) 1 (2.9) 0.49 (0.20–1.17) 0.106 0.39 (0.15–1.05) 0.062 1.16 (0.14–9.74) 0.893
GT 91 (24.7) 4 (11.4)       
GG 254 (69.0) 30 (85.7)       
ABCB1
 rs1045642 TT 52 (14.1) 5 (14.3) 0.71 (0.41–1.22) 0.217 0.54 (0.26–1.10) 0.091 0.96 (0.35–2.63) 0.941
CT 177 (48.1) 12 (34.3)       
CC 133 (36.1) 17 (48.6)       
ABCC2
 rs717620 AA 11 (3.0) 1 (2.9) 0.79 (0.38–1.61) 0.510 0.73 (0.32–1.63) 0.438 1.09 (0.13–8.81) 0.939
AG 111 (30.2) 8 (22.9)       
GG 231 (62.8) 23 (65.7)       
 rs2273697 AA 2 (0.5) 0 (0.0) 1.94 (0.93–4.04) 0.078 2.10 (0.97–4.53) 0.060 0.00 0.999
AG 61 (16.6) 11 (31.4)       
GG 304 (82.6) 24 (68.6)       
 rs3740066 AA 12 (3.3) 2 (5.7) 0.91 (0.47–1.79) 0.795 0.76 (0.35–1.67) 0.500 2.25 (0.47–10.75) 0.309
AG 116 (31.5) 8 (22.9)       
GG 229 (62.2) 23 (65.7)       
MATE1
 rs2289669 AA 79 (21.5) 10 (28.6) 1.35 (0.80–2.28) 0.254 1.55 (0.62–3.89) 0.350 1.44 (0.66–3.16) 0.363
AG 187 (50.8) 18 (51.4)       
GG 87 (23.6) 6 (17.1)       
  1. OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1
Gene SNP Genotype Hematological toxicity
Grade 1–2 [cases (%)] Grade 3–4 [cases (%)] Additive model Dominant model Recessive model
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total   308 95       
OCT2
 rs316003 CC 17 (5.5) 2 (2.1) 0.75 (0.49–1.15) 0.190 0.78 (0.47–1.28) 0.324 0.37 (0.08–1.67) 0.196
CT 103 (33.4) 31 (32.6)       
TT 176 (57.1) 59 (62.1)       
 rs316019 TT 9 (2.9) 0 (0.0) 0.58 (0.34–0.97) 0.039 0.61 (0.34–1.07) 0.085 0.00 0.998
GT 75 (24.4) 20 (21.1)       
GG 209 (67.9) 75 (78.9)       
ABCB1
 rs1045642 TT 44 (14.3) 13 (13.7) 0.92 (0.65–1.31) 0.648 0.87 (0.53–1.41) 0.560 0.97 (0.49–1.93) 0.936
CT 147 (47.7) 42 (44.2)       
CC 111 (36.0) 39 (41.1)       
ABCC2          
 rs717620 AA 8 (2.6) 4 (4.2) 1.15 (0.74–1.78) 0.546 1.09 (0.66–1.81) 0.736 1.88 (0.53–6.72) 0.330
AG 91 (29.5) 28 (29.5)       
GG 196 (63.6) 58 (61.1)       
 rs2273697 AA 1 (0.3) 1 (1.1) 1.13 (0.64–1.98) 0.679 1.10 (0.60–1.99) 0.759 2.46 (0.15–40.00) 0.528
AG 54 (17.5) 18 (18.9)       
GG 252 (81.8) 76 (80.0)       
 rs3740066 AA 12 (3.9) 2 (2.1) 0.89 (0.58–1.38) 0.600 0.94 (0.57–1.55) 0.806 0.49 (0.11–2.27) 0.361
AG 94 (30.5) 30 (31.6)       
GG 192 (62.3) 60 (63.2)       
MATE1
 rs2289669 AA 58 (18.8) 31 (32.6) 1.30 (0.92–1.83) 0.141 0.99 (0.57–1.72) 0.973 1.92 (1.13–3.25) 0.016
AG 164 (53.2) 41 (43.2)       
GG 70 (22.7) 23 (24.2)       
  1. OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1
Gene SNP Genotype Overall toxicity
Grade 1–2 [cases (%)] Grade 3–4 [cases (%)] Additive model Dominant model Recessive model
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total   268 135       
OCT2
 rs316003 CC 14 (5.2) 5 (3.7) 0.85 (0.59–1.23) 0.400 0.86 (0.56–1.33) 0.502 0.66 (0.23–1.90) 0.446
CT 91 (34.0) 43 (31.9)       
TT 154 (57.5) 81 (60.0)       
 rs316019 TT 8 (3.0) 1 (0.7) 0.59 (0.37–0.93) 0.024 0.59 (0.36–0.98) 0.041 0.21 (0.03–1.75) 0.150
GT 68 (25.4) 27 (20.0)       
GG 179 (66.8) 105 (77.8)       
ABCB1
 rs1045642 TT 39 (14.6) 18 (13.3) 0.91 (0.67–1.24) 0.539 0.89 (0.58–1.38) 0.604 0.86 (0.47–1.58) 0.632
CT 126 (47.0) 63 (46.7)       
CC 98 (36.6) 52 (38.5)       
ABCC2
 rs717620 AA 7 (2.6) 5 (3.7) 1.04 (0.70–1.54) 0.838 1.00 (0.63–1.56) 0.985 1.52 (0.47–4.91) 0.489
AG 80 (29.9) 39 (28.9)       
GG 169 (63.1) 85 (63.0)       
 rs2273697 AA 1 (0.4) 1 (0.7) 1.49 (0.90–2.54) 0.118 1.50 (0.89–2.53) 0.128 2.30 (0.14–37.24) 0.557
AG 42 (15.7) 30 (22.2)       
GG 224 (83.6) 104 (77.0)       
 rs3740066 AA 11 (4.1) 3 (2.2) 0.86 (0.58–1.27) 0.446 0.88 (0.56–1.37) 0.573 0.58 (0.16–2.12) 0.409
AG 83 (31.0) 41 (30.4)       
GG 165 (61.6) 87 (64.4)       
MATE1
 rs2289669 AA 50 (18.7) 39 (28.9) 1.30 (1.00–1.86) 0.052 1.28 (0.77–2.13) 0.335 1.73 (1.06–2.82) 0.029
AG 140 (52.2) 65 (48.1)       
GG 65 (24.3) 28 (20.7)       
  1. OCT2 organic cation transporter 2, ABCB1 ATP-binding cassette subfamily B member 1, ABCC2 ATP-binding cassette subfamily C member 2, MATE1 multidrug and toxin extrusion 1