Table 4 Multiple-adjusted HRs for OS by baseline BMI level, stratified by covariates
Stratification covariate | No. of patients | Underweight (HRa) | Normal weight [HR (95% CI)a] | Overweight/obese [HR (95% CI)a] | P b |
|---|---|---|---|---|---|
Age (years) | 0.675 | ||||
 <45 | 419 | 1.0 | 1.01 (0.74–1.38) | 0.74 (0.50–1.09) |  |
 ≥45 | 400 | 1.0 | 0.76 (0.55–1.06) | 0.54 (0.37–0.79) |  |
Sex | 0.680 | ||||
 Men | 681 | 1.0 | 0.82 (0.64–1.04) | 0.59 (0.44–0.79) |  |
 Women | 138 | 1.0 | 1.29 (0.67–2.45) | 0.93 (0.45–1.94) |  |
UICC T category | 0.471 | ||||
 T1–2 | 369 | 1.0 | 0.84 (0.60–1.17) | 0.78 (0.52–1.17) |  |
 T3–4 | 450 | 1.0 | 0.88 (0.65–1.19) | 0.49 (0.34–0.70) |  |
UICC N category | 0.501 | ||||
 N0–1 | 417 | 1.0 | 0.83 (0.61–1.14) | 0.55 (0.37–0.82) |  |
 N2–3 | 402 | 1.0 | 0.86 (0.60–1.18) | 0.67 (0.46–0.98) |  |
Metastasis onset | 0.551 | ||||
 Synchronous | 272 | 1.0 | 0.94 (0.60–1.49) | 0.55 (0.33–0.90) |  |
 Metachronous | 547 | 1.0 | 0.80 (0.62–1.04) | 0.67 (0.48–0.92) |  |
Lung metastasis | 0.761 | ||||
 Absent | 469 | 1.0 | 0.92 (0.69–1.24) | 0.66 (0.46–0.95) |  |
 Present | 350 | 1.0 | 0.78 (0.54–1.12) | 0.62 (0.40–0.94) |  |
Liver metastasis | 0.098 | ||||
 Absent | 574 | 1.0 | 0.70 (0.54–0.91) | 0.45 (0.32–0.62) |  |
 Present | 245 | 1.0 | 1.39 (0.22–2.19) | 1.46 (0.88–2.43) |  |
Bone metastasis | 0.051 | ||||
 Absent | 382 | 1.0 | 0.83 (0.58–1.18) | 0.76 (0.50–1.14) |  |
 Present | 437 | 1.0 | 0.91 (0.68–1.23) | 0.57 (0.39–0.82) |  |
Solitary lesion | 0.062 | ||||
 No | 701 | 1.0 | 0.90 (0.72–1.14) | 0.60 (0.45–0.80) |  |
 Yes | 118 | 1.0 | 0.35 (0.14–0.86) | 0.44 (0.17–1.13) |  |
Number of involved sites | 0.331 | ||||
 One | 545 | 1.0 | 0.72 (0.57–0.99) | 0.53 (0.38–0.74) |  |
 Two or more | 274 | 1.0 | 1.11 (0.75–1.66) | 0.84 (0.52–1.33) |  |
Treatment modality | 0.055 | ||||
 CT | 607 | 1.0 | 0.92 (0.71–1.19) | 0.56 (0.41–0.77) |  |
 CT + LT | 212 | 1.0 | 0.74 (0.46–1.21) | 0.89 (0.52–1.52) |  |