Fig. 4

Intratumoral injection of EYA4-expressing plasmids suppressed RBE- and SSP-25-derived xenograft tumor growth in vivo. a Intra-tumoral injection of EYA4 plasmids (EYA4 group) led to slower tumor growth at nearly all examined time points compared with vector and blank groups (P = 0.001 and P = 0.033, respectively); b After six treatments by intratumoral injection, the volume of tumors in the EYA4 group (bottom) was significantly smaller than those in the vector (middle) and blank groups (top, P = 0.001 for RBE and P = 0.011 for SSP, respectively). c Tumor weights in the EYA4 group were significantly smaller than those in vector and blank groups (*P = 0.004 for RBE and *P = 0.036 for SSP, respectively). d Adverse effects of EYA4-expressing plasmid treatment were evaluated by mice body weight, and no differences are observed among EYA4, vector and blank groups (P = 0.617 for RBE and P = 0.924 for SSP, respectively)