Table 1 Tumor characteristics and treatment of patients with unresectable locally advanced sigmoid colon cancer
Case | Sex/age (years) | cTNM | Involved structures | Therapy prior to enrollmenta (response) | RT (technique, Gy per faction) | Concurrent chemotherapya | Surgery | Resection status | ypTNM | Adjuvant chemotherapya | OS (ms)/status | ECOG PS score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F/43 | cT4bN2M0 | Bladder, pelvic wall | No | 3D-CRT, 46/23 | XELOX × 2 | Colectomy | R0 | ypT0N0M0 | XELOX × 5 | 49/FOD | 1 |
2 | M/63 | cT4bN2M0 | Bladder | No | VMAT, 50/25 | XELOX × 2 | Colectomy | R0 | ypT0N0M0 | XELOX × 5 | 36/FOD | 1 |
3 | M/59 | cT4aN1M0 | No | No | VMAT, 50/25 | XELOX × 2 | Colectomy | R0 | ypT0N0M0 | XELOX × 1 | 39/FOD | 0 |
4 | M/58 | cT3N2M0 | No | No | VMAT, 50/25 | XELOX × 2 + Xeloda × 1 | Colectomy | R0 | ypT0N0M0 | No | 33/FOD | 0 |
5 | M/43 | cT4aN2M0 | No | No | VMAT, 50/25 | XELOX × 3 | Colectomy | R0 | ypT3N0M0 | XELOX × 5 | 30/FOD | 1 |
6 | M/50 | cT4aN2M1 | No | No | VMAT, 50/25 | XELOX × 4 | Colectomy | R0 | ypT3N0M1 | FOLFIRI + C225 × 8 | 28/AWD | 0 |
7 | F/67 | cT3N2M0 | No | No | VMAT, 50/25 | XELOX × 2 | Colectomy | R0 | ypT2N0M0 | No | 36/FOD | 0 |
8 | M/67 | cT4bN2M0 | Bladder, ureter | No | VMAT, 50/25 | XELOX × 2 | Colectomy + partial cystectomy + partial ureterectomy | R0 | ypT4bN0M0 | XELOX × 1 | 32/FOD | 1 |
9 | M/67 | cT4aN1M1 | No | No | VMAT, 50/25 | XELOX × 4 | Colectomy | R0 | ypT3N0M1 | XELOX × 2 | 17/DOD | – |
10 | M/70 | cT4aN1M1 | No | No | VMAT, 50/25 | XELOX × 4 | Colectomy | R0 | ypT3N0M1 | No | 28/AWD | 2 |
11 | M/47 | cT4aN1M0 | No | No | VMAT, 50/25 | XELOX × 4 | Colectomy | R0 | ypT0N0M0 | XELOX × 2 | 21/FOD | 0 |
12 | F/63 | cT4bN0M0 | Uterus, ureter | No | VMAT, 50/25 | XELOX × 3 | Colectomy + partial ureterectomy | R0 | ypT1N0M0 | XELOX × 1 | 21/FOD | 0 |
13 | F/50 | cT4aN2M0 | No | No | VMAT, 50/25 | XELOX × 4 | Colectomy | R0 | YpT0N0M0 | XELOX × 1 | 21/FOD | 0 |
14 | M/30 | cT4bN1M0 | Bladder | Sigmoidostomy | 3D-CRT,46/23 | XELOX × 2 | Colectomy + partial cystectomy | R0 | ypT0N0M0 | XELOX × 5 | 35/FOD | 0 |
15 | M/49 | cT4bN1M0 | Iliac vessels, ureter, ileum | Colostomy | VMAT, 50/25 | XELOX × 2 + Xeloda × 1 | Colectomy + partial cystectomy + partial ileectomy | R0 | ypT3N0M0 | XELOX × 2 | 36/FOD | 1 |
16 | F/66 | cT4bN2M0 | Bladder, uterus | Colostomy | 3D-CRT, 46/23 | XELOX × 4 | Colectomy | R0 | ypT3N0M0 | No | 36/FOD | 0 |
17 | M/52 | cT4bN2M0 | Bladder, ureter | Colostomy | 3D-CRT, 46/23 | XELOX × 2 | Colectomy | R0 | ypT3N0M0 | XELOX × 4, xeloda × 2 | 36/FOD | 0 |
18 | M/44 | cT4bN2M0 | Bladder, pelvic wall | Sigmoidostomy | 3D-CRT, 46/23 | XELOX × 2 | Colectomy + biopsy | R2 | ypT4aN0M1 | No | 39/AWD | 1 |
19 | M/52 | cT4bN2M0 | Bladder | Sigmoidostomy, mFOLFOX × 6 (SD) | VMAT, 50/25 | CPT11 + Xeloda × 2 | Colectomy + partial cystectomy | R0 | ypT0N0M0 | Xeloda × 1 | 36/FOD | 1 |
20 | M/67 | cT4bN1M0 | Bladder | Sigmoidostomy, mFOLFOX × 4 (SD), FOLFOXIRI × 3 (SD) | VMAT, 50/25 | XELOX × 2 | Colectomy + partial cystectomy | R0 | ypT3N0M0 | – | 39/FOD | 1 |
21 | M/74 | cT4bN2M0 | Bladder, abdominal wall | XELOX × 4 (SD) | VMAT, 50/25 | XELOX × 2 | Colectomy + partial cystectomy | R0 | ypT3N0M0 | Xeloda × 2 | 41/FOD | 0 |