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Table 1 Characteristics of 204 patients with locally recurrent nasopharyngeal carcinoma

From: A model to predict the risk of lethal nasopharyngeal necrosis after re-irradiation with intensity-modulated radiotherapy in nasopharyngeal carcinoma patients

Characteristic All (n = 204) LNN (n = 31) Non-LNN (n = 173)
Sex
 Men 160 (78.4) 18 (58.1) 142 (82.1)
 Women 44 (21.6) 13 (41.9) 31 (17.9)
Age (years)
 <39.5 48 (23.5) 4 (12.9) 44 (25.4)
 ≥39.5 156 (76.5) 27 (87.1) 129 (74.6)
Initial radiation dose (Gy)
 <74.68 178 (87.3) 25 (80.6) 153 (88.4)
 ≥74.68 26 (12.7) 6 (19.4) 20 (11.6)
Recurrent stage
 I 13 (6.4) 0 (0) 13 (7.5)
 II 25 (12.3) 4 (12.9) 21 (12.1)
 III 78 (38.2) 13 (41.9) 65 (37.6)
 IV 88 (43.1) 14 (45.2) 74 (42.8)
Interval of recurrence (months)
 <25.5 73 (35.8) 9 (29.0) 64 (37.0)
 ≥25.5 131 (64.2) 22 (72.0) 109 (63.0)
CCRT during re-irradiation
 Yes 67 (32.8) 8 (25.8) 59 (34.1)
 No 137 (67.2) 23 (74.2) 114 (65.9)
Necrosis before re-irradiation
 Yes 41 (20.1) 12 (38.7) 29 (16.8)
 No 163 (79.9) 19 (61.3) 144 (83.2)
Re-irradiation dose (Gy)
 <67 135 (66.2) 18 (58.1) 117 (67.6)
 ≥67 69 (33.8) 13 (41.9) 56 (32.4)
Mean re-irradiation dose (Gy)
 <71.97 152 (74.5) 18 (58.1) 134 (77.5)
 ≥71.97 52 (25.5) 13 (41.9) 39 (22.5)
Re-irradiation fractionated dose (Gy)
 <2.3 197 (96.6) 30 (96.8) 167 (96.5)
 ≥2.3 7 (3.4) 1 (3.2) 6 (3.5)
Duration of re-irradiation (days)
 <49.5 173 (84.8) 23 (74.2) 150 (86.7)
 ≥49.5 31 (15.2) 8 (25.8) 23 (13.3)
Accumulated total GTV dose (Gy)
 <141.5 186 (91.2) 25 (80.6) 161 (93.1)
 ≥141.5 18 (8.8) 6 (19.4) 12 (6.9)
Recurrent tumor volume (cm3)
 <25.38 59 (28.9) 3 (9.7) 56 (32.4)
 ≥25.38 145 (71.1) 28 (90.3) 117 (67.6)
BMI
 <19.8 50 (24.5) 6 (19.4) 44 (25.4)
 ≥19.8 154 (75.5) 25 (80.6) 129 (74.6)
Necrosis
 Yes 77 (37.7) 31 (100) 46 (26.6)
 No 127 (62.2) 0 (0) 127 (73.4)
  1. All values are presented as the number of patients followed by percentage in the parentheses
  2. LNN lethal nasopharyngeal necrosis, CCRT concurrent chemoradiotherapy, GTV gross tumor volume, BMI body mass index