Table 1 Characteristics of 204 patients with locally recurrent nasopharyngeal carcinoma
Characteristic | All (n = 204) | LNN (n = 31) | Non-LNN (n = 173) |
|---|---|---|---|
Sex | |||
 Men | 160 (78.4) | 18 (58.1) | 142 (82.1) |
 Women | 44 (21.6) | 13 (41.9) | 31 (17.9) |
Age (years) | |||
 <39.5 | 48 (23.5) | 4 (12.9) | 44 (25.4) |
 ≥39.5 | 156 (76.5) | 27 (87.1) | 129 (74.6) |
Initial radiation dose (Gy) | |||
 <74.68 | 178 (87.3) | 25 (80.6) | 153 (88.4) |
 ≥74.68 | 26 (12.7) | 6 (19.4) | 20 (11.6) |
Recurrent stage | |||
 I | 13 (6.4) | 0 (0) | 13 (7.5) |
 II | 25 (12.3) | 4 (12.9) | 21 (12.1) |
 III | 78 (38.2) | 13 (41.9) | 65 (37.6) |
 IV | 88 (43.1) | 14 (45.2) | 74 (42.8) |
Interval of recurrence (months) | |||
 <25.5 | 73 (35.8) | 9 (29.0) | 64 (37.0) |
 ≥25.5 | 131 (64.2) | 22 (72.0) | 109 (63.0) |
CCRT during re-irradiation | |||
 Yes | 67 (32.8) | 8 (25.8) | 59 (34.1) |
 No | 137 (67.2) | 23 (74.2) | 114 (65.9) |
Necrosis before re-irradiation | |||
 Yes | 41 (20.1) | 12 (38.7) | 29 (16.8) |
 No | 163 (79.9) | 19 (61.3) | 144 (83.2) |
Re-irradiation dose (Gy) | |||
 <67 | 135 (66.2) | 18 (58.1) | 117 (67.6) |
 ≥67 | 69 (33.8) | 13 (41.9) | 56 (32.4) |
Mean re-irradiation dose (Gy) | |||
 <71.97 | 152 (74.5) | 18 (58.1) | 134 (77.5) |
 ≥71.97 | 52 (25.5) | 13 (41.9) | 39 (22.5) |
Re-irradiation fractionated dose (Gy) | |||
 <2.3 | 197 (96.6) | 30 (96.8) | 167 (96.5) |
 ≥2.3 | 7 (3.4) | 1 (3.2) | 6 (3.5) |
Duration of re-irradiation (days) | |||
 <49.5 | 173 (84.8) | 23 (74.2) | 150 (86.7) |
 ≥49.5 | 31 (15.2) | 8 (25.8) | 23 (13.3) |
Accumulated total GTV dose (Gy) | |||
 <141.5 | 186 (91.2) | 25 (80.6) | 161 (93.1) |
 ≥141.5 | 18 (8.8) | 6 (19.4) | 12 (6.9) |
Recurrent tumor volume (cm3) | |||
 <25.38 | 59 (28.9) | 3 (9.7) | 56 (32.4) |
 ≥25.38 | 145 (71.1) | 28 (90.3) | 117 (67.6) |
BMI | |||
 <19.8 | 50 (24.5) | 6 (19.4) | 44 (25.4) |
 ≥19.8 | 154 (75.5) | 25 (80.6) | 129 (74.6) |
Necrosis | |||
 Yes | 77 (37.7) | 31 (100) | 46 (26.6) |
 No | 127 (62.2) | 0 (0) | 127 (73.4) |