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Table 2 Univariate and multivariate analyses of prognostic values of clinicopathologic features and CEP78 expression for overall survival of CRC patients

From: Low expression of centrosomal protein 78 (CEP78) is associated with poor prognosis of colorectal cancer patients

Variable Univariate analysis Multivariate analysis
HR (95 % CI) P value HR (95 % CI) P value
Age (≤50 years vs. >50 years) 0.994 (0.658–1.501) 0.976   
Gender (female vs. male) 1.072 (0.719–1.597) 0.733   
Tumor size (≤4 cm vs. >4 cm) 2.125 (1.273–3.548) 0.004 1.873 (1.095–3.323) 0.022
Tumor differentiation (well vs. moderate vs. poor) 0.214 (0.029–1.574) 0.096   
Depth of tumor (T1 + T2 vs. T3 + T4) 4.881 (2.129–11.19) <0.001 0.815 (0.450–1.477) 0.500
Lymphatic metastasis (absent vs. present) 3.714 (2.351–5.865) <0.001 1.537 (0.830–2.847) 0.172
Distant metastasis (absent vs. present) 4.954 (3.283–7.475) <0.001 2.744 (1.701–4.425) <0.001
TNM stage (I + II vs. III + IV) 7.373 (4.003–13.58) <0.001 3.642 (1.492–8.894) 0.005
CEP78 expression (low vs. high) 0.520 (0.318–0.852) 0.009 0.787 (0.475–1.305) 0.354
  1. HR hazard ratio, CI confidence interval