Table 4 Cox proportional regression analysis of the associations between patient characteristics and OS in all 6031 NPC patients
From: A new prognostic histopathologic classification of nasopharyngeal carcinoma
Characteristic | Patients [cases (%)] | OS rate (%) | Unadjusted HR | 95% CI | P value | Adjusted HRa | 95% CI | P value | |
|---|---|---|---|---|---|---|---|---|---|
5-year | 95% CI | ||||||||
Proposed classification | |||||||||
 EC | 3708 (61.5) | 79.4 | 78.1–80.8 | 1.00 | Reference |  | 1.00 | Reference |  |
 MSEC | 1247 (20.7) | 70.5 | 67.7–73.0 | 1.48 | 1.32–1.67 | <0.001 | 1.44 | 1.27–1.62 | <0.001 |
 SC | 823 (13.6) | 59.6 | 55.9–63.1 | 2.16 | 1.90–2.44 | <0.001 | 2.00 | 1.76–2.28 | <0.001 |
 SCC | 253 (4.2) | 42.6 | 35.8–49.3 | 3.56 | 2.96–4.28 | <0.001 | 4.23 | 3.34–5.38 | <0.001 |
Age | |||||||||
 ≤47 years | 3163 (52.5) | 77.8 | 76.3–79.3 | 1.00 | Reference |  | 1.00 | Reference |  |
 >47 years | 2868 (47.5) | 68.4 | 66.6–70.2 | 1.54 | 1.40–1.70 | <0.001 | 1.50 | 1.36–1.65 | <0.001 |
Sex | |||||||||
 Male | 4468 (74.1) | 71.7 | 70.3–73.1 | 1.00 | Reference |  | 1.00 | Reference |  |
 Female | 1563 (25.9) | 78.1 | 75.8–80.2 | 0.73 | 0.65–0.81 | <0.001 | 0.76 | 0.68–0.86 | <0.001 |
Therapeutic modality | |||||||||
 Radiotherapy alone | 2739 (45.4) | 71.4 | 69.6–73.1 | 1.00 | Reference |  | 1.00 | Reference |  |
 Radiochemotherapy | 3292 (54.6) | 75.2 | 73.4–76.8 | 0.88 | 0.79–0.97 | 0.009 | 0.65 | 0.59–0.72 | <0.001 |
Clinical stage | |||||||||
 I | 177 (2.9) | 92.4 | 87.1–95.5 | 1.00 | Reference |  | 1.00 | Reference |  |
 II | 1041 (17.3) | 85.6 | 83.2–87.6 | 2.20 | 1.27–3.79 | 0.004 | 2.25 | 1.3–3.89 | 0.003 |
 III | 2424 (40.2) | 74.3 | 72.4–76.0 | 4.17 | 2.46–7.08 | <0.001 | 4.70 | 2.76–7.98 | <0.001 |
 IV | 2389 (39.6) | 64.9 | 62.7–67.0 | 5.77 | 3.40–9.78 | <0.001 | 6.96 | 4.09–11.85 | <0.001 |
WHO classification | |||||||||
 NKUC | 4871 (80.8) | 73.8 | 72.5–75.1 | 1.00 | Reference |  | 1.00 | Reference |  |
 NKDC | 1050 (17.4) | 73.2 | 70.1–75.9 | 1.02 | 0.90–1.16 | 0.729 | 1.00 | 0.87–1.16 | 0.980 |
 KSCC | 110 (1.8) | 57.5 | 47.0–66.6 | 1.85 | 1.38–2.47 | <0.001 | 0.51 | 0.35–0.74 | <0.001 |