Forty-six cases of nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative: 20 years of follow-up and outcomes from the Sun Yat-sen University Cancer Center

Table 4 Acute and late toxicities in the 46 NPC patients treated with 50 Gy radiotherapy plus hematoporphyrin derivative

Toxicity	Grade 0	Grade 1	Grade 2	Grade 3	Grade 4
Acute toxicities
Skin (dermatitis)	0	32 (69.6)	8 (17.4)	6 (13.0)	0
Mucositis	0	16 (34.8)	20 (43.5)	10 (21.7)	0
Xerostomia	0	33 (71.7)	13 (28.3)	0	0
Hearing loss	40 (87.0)	6 (13.0)	0	0	0
Late toxicities^a
Temporal lobe necrosis	42 (100)	0	0	0	0
Cranial nerve palsy	42 (100)	0	0	0	0
Optic nerve/chiasm injury	42 (100)	0	0	0	0
Brainstem injury	42 (100)	0	0	0	0
Hypopituitarism	42 (100)	0	0	0	0
Hypothyroidism	42 (100)	0	0	0	0
Trismus	35 (83.3)	7 (16.7)	0	0	0
Neck fibrosis	36 (85.7)	6 (14.3)	0	0	0
Xerostomia	3 (7.1)	38 (90.5)	1 (2.4)	0	0
Hearing loss	5 (11.9)	35 (83.3)	2 (4.8)	0	0

All values are presented as the numbers of patients followed by percentages in the parentheses
^a The 42 patients who were followed up for at least 10 years are included in the analysis of late toxicities

ISSN: 2523-3548