Table 1 Roles of the stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP₃Rs) in tumor invasion and metastasis

STIM-ORAI

Human breast cancer MDR-MB-231 and MCF-10A cells

Regulates focal adhesion (FA) turnover and increases tumor cell migration

[31]

Human glioblastoma multiforme (GBM) U251-MG, SNB19, U87, and LN229 cells

Regulates GBM cell invasiveness and increases tumor metastasis

[32]

Regulates FA turnover and epithelial-to-mesenchymal transition

[57]

Clear cell renal cell carcinoma (RCC)

Regulates migration and proliferation; increases RCC development

[36]

Human colorectal cancer (CRC)

Associated with tumor size, lymph node metastasis, and serum levels of carcinoembryonic antigen; promotes CRC migration; remolds Ca²⁺ signal and channel features

[48]

Pancreatic adenocarcinoma Panc1 cells

Protects tumor against apoptosis

[49]

Human melanoma SK-Mel-2 and SK-Mel-24 cells

Promotes melanoma cells proliferation and migration

[50]

ORAI

Human prostate epithelial cell line DU145 cells

Alters the molecular components of ORAI; increases ORAI1:ORAI3 ratio; and is associated with negative prognosis

[9]

Human esophageal squamous cell carcinoma KYSE-150, -190, -30, -510, and -790 cells

Regulates cell proliferation, migration, and invasion; promotes tumor growth; and is associated with recurrence rate

[43]

STIM1

Hepatocellular carcinoma (HCC) HepG2, Hep3B, HCC-LM3, and Huh7 cells

Enhances FA turnover; increases HCC migration

[34]

Non-small cell lung cancer A549 and H460 cells

Knocks down STIM1; enhances the apoptosis induced by cisplatin

[40]

IP₃R

Estradiol-induced breast cancer MCF-7 cells

Inhibits the growth of MCF-7 cells via the IP₃R inhibitor caffeine

[63]

Glioblastoma cells

blocks the glioblastoma invasion and migration via inhibiting the functions of IP₃R

[71]

Colorectal cancer cell lines HCT116 and DLD-1 cells

IP₃R isoform is remodeled by oncogenic k-Ras; increases resistance to apoptosis

[72]

Colorectal carcinoma

Increases resistance to apoptosis-mediated Ca²⁺ signal between the endoplasmic reticulum and mitochondria

[78]