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Table 1 Roles of the stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in tumor invasion and metastasis

From: Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?

Channel Cell type(s) Mechanism and function References
STIM-ORAI Human breast cancer MDR-MB-231 and MCF-10A cells Regulates focal adhesion (FA) turnover and increases tumor cell migration [31]
Human glioblastoma multiforme (GBM) U251-MG, SNB19, U87, and LN229 cells Regulates GBM cell invasiveness and increases tumor metastasis [32]
Regulates FA turnover and epithelial-to-mesenchymal transition [57]
Clear cell renal cell carcinoma (RCC) Regulates migration and proliferation; increases RCC development [36]
Human colorectal cancer (CRC) Associated with tumor size, lymph node metastasis, and serum levels of carcinoembryonic antigen; promotes CRC migration; remolds Ca2+ signal and channel features [48]
Pancreatic adenocarcinoma Panc1 cells Protects tumor against apoptosis [49]
Human melanoma SK-Mel-2 and SK-Mel-24 cells Promotes melanoma cells proliferation and migration [50]
ORAI Human prostate epithelial cell line DU145 cells Alters the molecular components of ORAI; increases ORAI1:ORAI3 ratio; and is associated with negative prognosis [9]
Human esophageal squamous cell carcinoma KYSE-150, -190, -30, -510, and -790 cells Regulates cell proliferation, migration, and invasion; promotes tumor growth; and is associated with recurrence rate [43]
STIM1 Hepatocellular carcinoma (HCC) HepG2, Hep3B, HCC-LM3, and Huh7 cells Enhances FA turnover; increases HCC migration [34]
Non-small cell lung cancer A549 and H460 cells Knocks down STIM1; enhances the apoptosis induced by cisplatin [40]
IP3R Estradiol-induced breast cancer MCF-7 cells Inhibits the growth of MCF-7 cells via the IP3R inhibitor caffeine [63]
Glioblastoma cells blocks the glioblastoma invasion and migration via inhibiting the functions of IP3R [71]
Colorectal cancer cell lines HCT116 and DLD-1 cells IP3R isoform is remodeled by oncogenic k-Ras; increases resistance to apoptosis [72]
Colorectal carcinoma Increases resistance to apoptosis-mediated Ca2+ signal between the endoplasmic reticulum and mitochondria [78]