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Table 6 Relationship between clinical characteristics and OS/DFS in patients with undetectable or low baseline HBV DNA levels (<2000 IU/mL), as determined by univariate and multivariate Cox regression analysis

From: Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Variable OS DFS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR P value HR (95 % CI) P value HR P value HR (95 % CI) P value
Age (≥50 vs. <50 years) 1.173 0.566    0.750 0.183   
Gender (female vs. male) 0.819 0.645    0.963 0.902   
HBeAg (positive vs. negative) 1.321 0.554    1.407 0.330   
Tumor size (≥5 or <5 cm) 2.013 0.013 Not significant   1.772 0.006 1.997 (1.295–3.044) 0.002
Tumor number (multiple vs. single) 2.612 0.013 Not significant   2.194 0.015 2.761 (1.440–5.296) 0.002
Pathologic grades (IV/III/II/I) 1.535 0.073 Not significant   1.346 0.100 Not significant  
Microvascular thrombus (yes vs. no) 1.902 0.140    1.561 0.205   
Tumor capsule (without/incomplete/complete) 1.046 0.784    0.873 0.284   
AFP (>25 vs. ≤25 ng/mL) 1.084 0.777    1.230 0.345   
ALT (>40 vs. ≤40 IU/L) 1.219 0.487    1.115 0.618   
AST (>45 vs. ≤45 IU/L) 0.820 0.626    1.107 0.712   
ALB (≥35 vs. <35 g/L) 0.490 0.324    0.712 0.562   
TBIL (>20.5 vs. ≤20.5 μmol/L) 1.167 0.661    1.439 0.158   
Prothrombin time (>13.5 vs. ≤13.5 s) 1.296 0.432    1.272 0.342   
Antiviral treatment (yes vs. no) 0.641 0.206    1.068 0.777   
Recurrence (yes vs. no) 5.859 <0.001 5.859 (3.007–11.416) <0.001     
  1. OS overall survival, DFS disease-free survival, CI confidence interval, HR hazard ratio, Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin