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Table 5 List of genes differentially expressed between the EGFR exon 19 deletion and exon 21 L858R mutation groups

From: Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21

Gene

Chromosome

Reference base

Mutated base

Mutation frequency

P valuea

EGFR 19 deletion

Exon 21 L858R mutation

Difference

EGFR

7

T

0

1

1

0.000

PARP1

1

A

G

0.583

0.083

0.5

0.027

SPEN

1

T

C

0.417

0

0.417

0.037

SPEN

1

A

G

0.417

0

0.417

0.037

IGF1R

15

GGT

G

0.417

0

0.417

0.037

NOS3

7

C

G

0.583

0

0.583

0.005

KMT2D

12

G

A

0.417

0

0.417

0.037

IGF1R

15

G

A

0.417

0

0.417

0.037

SUFU

10

G

A

0.583

0.083

0.5

0.027

EP300

22

T

C

0.583

0.083

0.5

0.027

SPEN

1

A

G

0.417

0

0.417

0.037

ACVR1B

12

C

T

0.417

0

0.417

0.037

FLT1

13

T

C

0.417

0

0.417

0.037

IGF1R

15

T

C

0.417

0

0.417

0.037

RARA

17

C

T

0.417

0

0.417

0.037

CSF1R

5

G

A

0.417

0

0.417

0.037

ZC3HAV1

7

G

A

0.417

0

0.417

0.037

NOS3

7

T

G

0.5

0

0.5

0.014

ATG9B

7

G

T

0.583

0.083

0.5

0.027

PARP1

1

C

G

0.583

0.083

0.5

0.027

  1. aAnalyzed by using Fisher’s exact test