Fig. 3From: Future options of anti-angiogenic cancer therapyVEGF signaling and anti-VEGF drug targets. VEGF stimulates tumor angiogenesis by activating endothelial VEGFR2 and its downstream signaling. Drugs targeting various signaling components have been developed for clinical use. VEGF vascular endothelial growth factor, VEGFR2 vascular endothelial growth factor receptor 2Back to article page