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Table 9 Summary of p53 mutations detected in non-angiogenic and angiogenic NSCLC cases

From: Why some tumours trigger neovascularisation and others don’t: the story thus far

Sample ID Sample type Mutation location Mutation type Domain Predicted effect on protein activity
104 Non-angiogenic c.761T>TA; p.I254S Missense HCD IV Damaging
105 Non-angiogenic c.734G>GA; p.G245D Missense HCD IV Damaging
121 Non-angiogenic c.488A>AG; p.Y163C Missense DNA binding Damaging
152 Non-angiogenic c.634T>TG; p.F212 V Missense DNA binding Benign
249 Non-angiogenic c.314G>GA; p.G105D Missense DNA binding Damaging
133 Angiogenic c.511G>GT; p.E171X Nonsense (truncated protein) HCD III Truncating
138 Angiogenic c.824G>GA; p.C275Y Missense HCD IV Damaging
139 Angiogenic c.het_del216C; p.V73 Wfs48X Frameshift (truncated protein) Prolinerich Truncating
141 Angiogenic c.407A>AC; p.Q136P Missense HCD II Damaging
98 Angiogenic c.524G>GA; p.R175H Missense HCD III Potentially damaging
147 Angiogenic c.524G>GA; p.R175H Missense
274 Angiogenic c.471_472TC>GA; p.V157G Missense DNA binding Damaging
  1. Affected domains are listed. The software used to predict the functional effect of the detected sequence changes was PolyPhen_2 (http://genetics.bwh.harvard.edu/ggi/pph2/c2ea64efde6f039a5ca76a2a264ae4f3cf922360/1121012.html )
  2. HCD highly conserved domain