Table 9 Summary of p53 mutations detected in non-angiogenic and angiogenic NSCLC cases
From: Why some tumours trigger neovascularisation and others don’t: the story thus far
Sample ID | Sample type | Mutation location | Mutation type | Domain | Predicted effect on protein activity |
|---|---|---|---|---|---|
104 | Non-angiogenic | c.761T>TA; p.I254S | Missense | HCD IV | Damaging |
105 | Non-angiogenic | c.734G>GA; p.G245D | Missense | HCD IV | Damaging |
121 | Non-angiogenic | c.488A>AG; p.Y163C | Missense | DNA binding | Damaging |
152 | Non-angiogenic | c.634T>TG; p.F212 V | Missense | DNA binding | Benign |
249 | Non-angiogenic | c.314G>GA; p.G105D | Missense | DNA binding | Damaging |
133 | Angiogenic | c.511G>GT; p.E171X | Nonsense (truncated protein) | HCD III | Truncating |
138 | Angiogenic | c.824G>GA; p.C275Y | Missense | HCD IV | Damaging |
139 | Angiogenic | c.het_del216C; p.V73 Wfs48X | Frameshift (truncated protein) | Prolinerich | Truncating |
141 | Angiogenic | c.407A>AC; p.Q136P | Missense | HCD II | Damaging |
98 | Angiogenic | c.524G>GA; p.R175H | Missense | HCD III | Potentially damaging |
147 | Angiogenic | c.524G>GA; p.R175H | Missense | ||
274 | Angiogenic | c.471_472TC>GA; p.V157G | Missense | DNA binding | Damaging |