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Table 6 Protein biomarker expression in angiogenic and non-angiogenic NSCLCs according to their intracellular localization

From: Why some tumours trigger neovascularisation and others don’t: the story thus far

Expression status Intracellular expression localization Proteins
Equal expression in both tumour types Nuclear VEGFA, TYMP, KDR, KDRp34, FIH, EPHB4, PHD1, SOD1, FGF, P53, SP1, STAT3, MEF2D, JMY, GST, CHGA
Cytoplasm HIF1, HIF2, VEGFA, TYMP, KDR, KDRp34, FIH, PHD1, SOD1, CXCR4, EPHB4, BCL2, EGF, EGFR, FGF, BNIP3, PI3, SP1, LON, MEF2D, GST, CHGA, SYP
Membrane CA9, MEF2D
Higher expression in angiogenic tumours than in non-angiogenic tumours in at least one subcellular location Nuclear HIF1, PHD2, PHD3, CXCR4, BNIP3, PI3, EGF, FOS
Cytoplasm PHD2, TSP (stroma), DLL4 (endothelium), FOS, STAT3
Membrane None
Higher expression in non-angiogenic tumours than in angiogenic tumours in at least one subcellular location Nuclear EPHB2, EPHB3,TRAP1
Cytoplasm CA9, PHD3, EPHB2, EPHB3, NCAM, P53, TRAP1, JMY
Membrane EPHB3, GST
  1. HIF hypoxia-inducible factor; CA9 carbonic anhydrase 9; VEGFA vascular endothelial growth factor A; TYMP thymidine phosphorylase; KDR vascular endothelial growth factor receptor 2; KDRp34 vascular endothelial growth factor p34; FIH factor-inhibiting HIF; PHD prolyl hydroxylase dehydrogenase; DLL4 Delta-like 4; TSP1 thymidine phosphorylase 1; CXCR4 chemokine (C-X-C motif) receptor 4; EPH ephrin; SOD1 superoxide dismutase 1; BCL2 B cell lymphoma 2; FOS FBJ murine osteosarcoma viral oncogene homolog; EGF epidermal growth factor; EGFR epidermal growth factor receptor; BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3; PI3 peptidase inhibitor 3; SP1 Sp1 transcription factor; STAT3 signal transducer and activator of transcription 3; LON Lon protease; MEF2D myocyte enhancer factor 2D; JMY junction-mediating and regulatory protein, p53 cofactor; TRAP1 TNF receptor-associated protein 1; GST glutathione S-transferase; NCAM neural cell adhesion molecule; CHGA chromogranin A; SYP synaptophysin