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Table 5 Nuclear expression of the proteins in angiogenic versus non-angiogenic NSCLCs

From: Why some tumours trigger neovascularisation and others don’t: the story thus far

Protein Intensity percentage score (IPS) of protein expression P value Tumour type with higher expression
Angiogenic tumours Non-angiogenic tumours
HIF1 5.49 ± 0.31 3.79 ± 0.39 0.01 Angiogenic
VEGFA 6.09 ± 0.52 5.62 ± 0.32 0.74
TYMP 1.94 ± 0.22 1.16 ± 0.21 0.42
KDR 231.20 ± 8.55 229.80 ± 9.88 >0.05
KDRp34 11.69 ± 0.16 11.45 ± 0.39 0.77
FIH 7.50 ± 0.35 8.15 ± 0.72 0.50
PHD1 3.10 ± 0.34 2.50 ± 0.35 0.99
PHD2 2.56 ± 0.27 1.41 ± 0.35 0.02 Angiogenic
PHD3 2.18 ± 0.13 0.65 ± 0.20 <0.001 Angiogenic
CXCR4 5.13 ± 0.23 3.72 ± 0.37 <0.01 Angiogenic
EPHB2 3.26 ± 0.26 4.91 ± 0.35 <0.001 Non-angiogenic
EPBH3 99.27 ± 7.41 147.30 ± 9.23 <0.001 Non-angiogenic
EPHB4 5.56 ± 0.30 5.73 ± 0.34 0.81
SOD1 4.21 ± 0.45 5.00 ± 0.91 0.44
C-FOS 7.50 ± 0.52 5.53 ± 0.75 0.05 Angiogenic
EGF 235.20 ± 5.60 214.8 ± 8.68 0.01 Angiogenic
FGF 7.51 ± 0.38 8.68 ± 0.76 0.11
BNIP3 3.96 ± 0.40 0.00 ± 0.00 <0.001 Angiogenic
P53 2.66 ± 0.36 2.32 ± 0.53 0.91
PI3 0.53 ± 0.13 0.00 ± 0.00 <0.02 Angiogenic
SP1 5.31 ± 0.46 4.04 ± 0.60 0.24
STAT3 7.80 ± 0.39 6.31 ± 0.81 0.09
MEF2D 251 ± 4.62 243.10 ± 8.04 0.38
JMY 2.01 ± 0.17 2.60 ± 0.27 0.07
TRAP1 1.57 ± 0.18 4.58 ± 0.32 <0.001 Non-angiogenic
GST 243.30 ± 6.15 244.10 ± 10.91 0.55
CHGA 0.00 ± 0.00 0.34 ± 0.12 >0.05
  1. All data are presented as mean ± standard error
  2. HIF hypoxia-inducible factor; CA9 carbonic anhydrase 9; VEGFA vascular endothelial growth factor A; TYMP thymidine phosphorylase; KDR vascular endothelial growth factor receptor 2; KDRp34 vascular endothelial growth factor p34; FIH factor-inhibiting HIF; PHD prolyl hydroxylasedehydrogenase; DLL4 Delta-like 4; TSP1 thymidine phosphorylase 1; CXCR4 chemokine (C-X-C motif) receptor 4; EPH ephrin; SOD1 superoxide dismutase 1; BCL2 B cell lymphoma 2; FOS FBJ murine osteosarcoma viral oncogene homolog; EGF epidermal growth factor; EGFR epidermal growth factor receptor; BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3; PI3 peptidase inhibitor 3; SP1 Sp1 transcription factor; STAT3 signal transducer and activator of transcription 3; LON Lon protease; MEF2D myocyte enhancer factor 2D; JMY junction-mediating and regulatory protein, p53 cofactor; TRAP1 TNF receptor-associated protein 1; GST glutathione S-transferase; NCAM neural cell adhesion molecule; CHGA chromogranin A; SYP synaptophysin
  3. Indicates equal expression