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Table 5 Nuclear expression of the proteins in angiogenic versus non-angiogenic NSCLCs

From: Why some tumours trigger neovascularisation and others don’t: the story thus far

Protein

Intensity percentage score (IPS) of protein expression

P value

Tumour type with higher expression

Angiogenic tumours

Non-angiogenic tumours

HIF1

5.49 ± 0.31

3.79 ± 0.39

0.01

Angiogenic

VEGFA

6.09 ± 0.52

5.62 ± 0.32

0.74

–

TYMP

1.94 ± 0.22

1.16 ± 0.21

0.42

–

KDR

231.20 ± 8.55

229.80 ± 9.88

>0.05

–

KDRp34

11.69 ± 0.16

11.45 ± 0.39

0.77

–

FIH

7.50 ± 0.35

8.15 ± 0.72

0.50

–

PHD1

3.10 ± 0.34

2.50 ± 0.35

0.99

–

PHD2

2.56 ± 0.27

1.41 ± 0.35

0.02

Angiogenic

PHD3

2.18 ± 0.13

0.65 ± 0.20

<0.001

Angiogenic

CXCR4

5.13 ± 0.23

3.72 ± 0.37

<0.01

Angiogenic

EPHB2

3.26 ± 0.26

4.91 ± 0.35

<0.001

Non-angiogenic

EPBH3

99.27 ± 7.41

147.30 ± 9.23

<0.001

Non-angiogenic

EPHB4

5.56 ± 0.30

5.73 ± 0.34

0.81

–

SOD1

4.21 ± 0.45

5.00 ± 0.91

0.44

–

C-FOS

7.50 ± 0.52

5.53 ± 0.75

0.05

Angiogenic

EGF

235.20 ± 5.60

214.8 ± 8.68

0.01

Angiogenic

FGF

7.51 ± 0.38

8.68 ± 0.76

0.11

–

BNIP3

3.96 ± 0.40

0.00 ± 0.00

<0.001

Angiogenic

P53

2.66 ± 0.36

2.32 ± 0.53

0.91

–

PI3

0.53 ± 0.13

0.00 ± 0.00

<0.02

Angiogenic

SP1

5.31 ± 0.46

4.04 ± 0.60

0.24

–

STAT3

7.80 ± 0.39

6.31 ± 0.81

0.09

–

MEF2D

251 ± 4.62

243.10 ± 8.04

0.38

–

JMY

2.01 ± 0.17

2.60 ± 0.27

0.07

–

TRAP1

1.57 ± 0.18

4.58 ± 0.32

<0.001

Non-angiogenic

GST

243.30 ± 6.15

244.10 ± 10.91

0.55

–

CHGA

0.00 ± 0.00

0.34 ± 0.12

>0.05

–

  1. All data are presented as mean ± standard error
  2. HIF hypoxia-inducible factor; CA9 carbonic anhydrase 9; VEGFA vascular endothelial growth factor A; TYMP thymidine phosphorylase; KDR vascular endothelial growth factor receptor 2; KDRp34 vascular endothelial growth factor p34; FIH factor-inhibiting HIF; PHD prolyl hydroxylasedehydrogenase; DLL4 Delta-like 4; TSP1 thymidine phosphorylase 1; CXCR4 chemokine (C-X-C motif) receptor 4; EPH ephrin; SOD1 superoxide dismutase 1; BCL2 B cell lymphoma 2; FOS FBJ murine osteosarcoma viral oncogene homolog; EGF epidermal growth factor; EGFR epidermal growth factor receptor; BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3; PI3 peptidase inhibitor 3; SP1 Sp1 transcription factor; STAT3 signal transducer and activator of transcription 3; LON Lon protease; MEF2D myocyte enhancer factor 2D; JMY junction-mediating and regulatory protein, p53 cofactor; TRAP1 TNF receptor-associated protein 1; GST glutathione S-transferase; NCAM neural cell adhesion molecule; CHGA chromogranin A; SYP synaptophysin
  3. – Indicates equal expression
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Cancer Communications

ISSN: 2523-3548

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