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Table 4 Cytoplasmic and membranous expression of the proteins in angiogenic versus non-angiogenic non-small cell lung cancers (NSCLCs)

From: Why some tumours trigger neovascularisation and others don’t: the story thus far

Protein Intensity percentage score (IPS) of protein expression P value Tumour type with higher expression
Angiogenic tumours Non-angiogenic tumours
HIF1 6.22 ± 0.33 6.00 ± 0.48 0.87
HIF2 0.00 ± 0.00 0.00 ± 0.00 Not applicable
CA9 cytoplasm 2.38 ± 0.16 3.50 ± 0.23 <0.001 Non-angiogenic
CA9 membrane 4.00 ± 0.40 3.30 ± 0.88 0.62
VEGFA 8.83 ± 0.35 7.38 ± 0.78 0.07
TYMP 3.20 ± 0.54 2.21 ± 0.32 0.28
KDR 94.56 ± 1.64 97.80 ± 1.54 >0.05
KDRp34 10.40 ± 0.30 10.55 ± 0.62 0.71
FIH 9.10 ± 0.32 10.00 ± 0.47 0.22
PHD1 3.74 ± 0.27 4.20 ± 0.48 0.47
PHD2 3.50 ± 0.30 2.46 ± 0.53 0.02 Angiogenic
PHD3 2.70 ± 0.09 3.38 ± 0.17 <0.001 Non-angiogenic
DLL4vessels 2.34 ± 0.10 1.53 ± 0.09 <0.001 Angiogenic
TSP stroma 16.98 ± 2.75 2.00 ± 1.74 <0.001 Angiogenic
CXCR4 2.47 ± 0.20 2.34 ± 0.31 0.92  
EPHB2 7.78 ± 0.27 9.06 ± 0.33 <0.01 Non-angiogenic
EPBH3 cytoplasm 159.3 ± 8.84 202.20 ± 9.95 <0.01 Non-angiogenic
EPBH3 membrane 23.83 ± 7.23 86.51 ± 12.78 <0.001 Non-angiogenic
EPHB4 7.82 ± 0.26 7.40 ± 0.38 0.57
SOD1 4.36 ± 0.45 9.39 ± 4.22 0.27
BCL2 1.05 ± 0.25 0.68 ± 0.35 0.54
FOS 8.05 ± 0.37 5.31 ± 0.55 <0.001 Angiogenic
EGFR 203.40 ± 10.79 166.30 ± 25.74 0.33
EGF 18.90 ± 3.03 14.44 ± 4.15 0.72
FGF 9.20 ± 0.42 9.72 ± 0.71 0.74
BNIP3 6.08 ± 0.36 5.92 ± 0.82 0.88
P53 0.28 ± 0.12 2.28 ± 0.56 <0.001 Non-angiogenic
PI3 4.62 ± 0.36 4.92 ± 0.61 0.51
SP1 3.70 ± 0.37 3.38 ± 0.55 0.86
STAT3 8.78 ± 0.39 7.11 ± 0.79 0.03 Angiogenic
LON 102.50 ± 11.20 134.20 ± 17.10 0.18
MEF2D cytoplasm 50.11 ± 4.16 65.67 ± 9.66 0.25
MEF2Dmembrane 60.00 ± 7.12 67.50 ± 12.67 0.47
JMY 1.84 ± 0.18 2.42 ± 0.31 0.05 Non-angiogenic
TRAP1 4.22 ± 0.28 5.48 ± 0.31 <0.01 Non-angiogenic
GST cytoplasm 236.20 ± 7.16 249.80 ± 11.40 0.23
GSTmembrane 28.44 ± 5.52 69.38 ± 14.03 <0.01 Non-angiogenic
NCAM 0.40 ± 0.09 3.92 ± 0.07 <0.001 Non-angiogenic
CHGA 0.08 ± 0.04 0.27 ± 0.14 >0.05
SYP 0.12 ± 0.05 0.44 ± 0.15 >0.05
  1. All data are presented as mean ± standard error
  2. HIF hypoxia-inducible factor; CA9 carbonic anhydrase 9; VEGFA vascular endothelial growth factor A; TYMP thymidine phosphorylase; KDR vascular endothelial growth factor receptor 2; KDRp34 vascular endothelial growth factor p34; FIH factor-inhibiting HIF; PHD prolyl hydroxylase dehydrogenase; DLL4 Delta-like 4; TSP1 thymidine phosphorylase 1; CXCR4 chemokine (C-X-C motif) receptor 4; EPH ephrin; SOD1 superoxide dismutase 1; BCL2 B cell lymphoma 2; FOS FBJ murine osteosarcoma viral oncogene homolog; EGF epidermal growth factor; EGFR epidermal growth factor receptor; BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3; PI3 peptidase inhibitor 3; SP1 Sp1 transcription factor; STAT3 signal transducer and activator of transcription 3; LON Lon protease; MEF2D myocyte enhancer factor 2D; JMY junction-mediating and regulatory protein, p53 cofactor; TRAP1 TNF receptor-associated protein 1; GST glutathione S-transferase; NCAM neural cell adhesion molecule; CHGA chromogranin A; SYP synaptophysin
  3. Indicates equal expression