Why some tumours trigger neovascularisation and others don’t: the story thus far

Cancer Communications

Table 2 Lists of proteins used for pathway visualization using the EnrichrWebd facility [21]

Expression status	Proteins
Equal expression in both tumour types	HIF2, VEGFA, TYMP, KDR, KDRp34, FIH, PHD1, SOD1, EPHB4, BCL2, EGFR, FGF, SP1, LON, MEF2D, RPSA^a, CHGA, SYP
Higher expression in angiogenic tumours than in non-angiogenic tumours in at least one subcellular location	HIF1, PHD2, PHD3 (cytoplasmic), CXCRN, TSP, DLL4, BNIP3, PI3, EGF, FOS, STAT3, ITGB3^a, ITGAV^a
Higher expression in non-angiogenic tumours than in angiogenic tumours in at least one subcellular location	CA9, PHD3 (nuclear), EPHB2, EPHB3, NCAM, P53, TRAP1, JMY, GST

FGF fibroblast growth factor; RPSA ribosomal protein SA; ITGB3 integrin, beta 3; ITGAV integrin alpha-V; HIF hypoxia-inducible factor; CA9 carbonic anhydrase 9; VEGFA vascular endothelial growth factor A; TYMP thymidine phosphorylase; KDR vascular endothelial growth factor receptor 2; KDRp34 vascular endothelial growth factor p34; FIH factor-inhibiting HIF; PHD prolyl hydroxylase dehydrogenase; DLL4 Delta-like 4; TSP1 thymidine phosphorylase 1; CXCR4 chemokine (C-X-C motif) receptor 4; EPH ephrin; SOD1 superoxide dismutase 1; BCL2 B cell lymphoma 2; FOS FBJ murine osteosarcoma viral oncogene homolog; EGF epidermal growth factor; EGFR epidermal growth factor receptor; BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3; PI3 peptidase inhibitor 3; SP1 Sp1 transcription factor; STAT3 signal transducer and activator of transcription 3; LON Lon protease; MEF2D myocyte enhancer factor 2D; JMY junction-mediating and regulatory protein, p53 cofactor; TRAP1 TNF receptor-associated protein 1; GST glutathione S-transferase; NCAM neural cell adhesion molecule; CHGA chromogranin A; SYP synaptophysin
^aData for RPSA are from Ref. [18] and for ITGB3 and ITGAV are from Ref. [23]

ISSN: 2523-3548