Fig. 1

Localization of the mutations detected on the p53 gene. The sequenced region is indicated with an orange line in the figure above. Mutation locations are indicated with arrowheads (purple mutations found in angiogenic samples; gray: mutations found in non-angiogenic samples). Human P53 protein (HP53) can be divided into five domains, each corresponding to specific functions: yellow is the highly conserved domain I (HCD I)/transactivation domain; red is the second transactivation domain, which is proline-rich; blue is the DNA-binding domain essential for p53-DNA interactions that also contains HCD II-V and is the target of 90% of the p53 mutations found in human cancers; green is the nuclear export signal (NES) localized in the oligomerization domain of p53