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Table 1 Parameters of the GdmCl-induced unfolding of ES variants

From: Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog

Protein

\(\rm\Delta {\text{G}}^{\text{o}}_{{{\text{N}}{-}{\text{U}}}}\) (kJ/mol)

m (kJ·L/mol2)

Cm (mol/L)

ES

29.23

12.88

2.27

ZBP-ES

24.16

10.70

2.26

M2ES

31.27

14.31

2.18

MZBP-ES

20.57

9.65

2.13

  1. GdmCl guanidinium chloride, \(\varDelta G^{o}_{{N{-}U}}\) the free change energy in the absence of GdmCl, m the apparent m value defined by the linear extrapolation model, C m the concentration of GdmCl at the midpoint of the unfolding transition, ES endostatin, ZBP-ES zinc-binding protein-ES, M 2 ES mono-PEGylated ES, MZBP-ES mono-PEGylated ZBP-ES
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Cancer Communications

ISSN: 2523-3548

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