Skip to main content

Advertisement

Table 3 Treatment-related toxicities in patients with locoregionally advanced NPC treated with NAC plus IMRT vs. CCRT plus AC

From: Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma: a retrospective controlled study

Toxicity NAC + IMRT
[cases (%)]
CCRT + AC
[cases (%)]
χ 2 P
Grade 3/4 acute toxicities
 Leukopenia 1 (0.9) 12 (9.8) 7.618 0.006
 Anemia 0 3 (2.4) 1.252 0.263
 Thrombocytopenia 1 (0.9) 4 (3.3) 0.719 0.397
 Hepatotoxicity 0 1 (0.8) 0.000 1.000
 Nausea–vomiting 2 (1.7) 10 (8.1) 5.204 0.023
 Mucositis 5 (4.3) 8 (6.5) 0.582 0.445
Late toxicities
 Skin dystrophy 37 (31.6) 51 (41.5) 2.500 0.114
 Subcutaneous fibrosis 26 (22.2) 29 (23.6) 0.062 0.803
 Xerostomia 68 (58.1) 85 (69.1) 3.132 0.077
 Hear loss 54 (46.2) 64 (52.0) 0.829 0.363
 Temporal lobe injury 4 (3.4) 6 (4.9) 0.059 0.809
  1. Abbreviations as in Table 1