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Table 3 Treatment-related toxicities in patients with locoregionally advanced NPC treated with NAC plus IMRT vs. CCRT plus AC

From: Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma: a retrospective controlled study

Toxicity

NAC + IMRT

[cases (%)]

CCRT + AC

[cases (%)]

χ 2

P

Grade 3/4 acute toxicities

 Leukopenia

1 (0.9)

12 (9.8)

7.618

0.006

 Anemia

0

3 (2.4)

1.252

0.263

 Thrombocytopenia

1 (0.9)

4 (3.3)

0.719

0.397

 Hepatotoxicity

0

1 (0.8)

0.000

1.000

 Nausea–vomiting

2 (1.7)

10 (8.1)

5.204

0.023

 Mucositis

5 (4.3)

8 (6.5)

0.582

0.445

Late toxicities

 Skin dystrophy

37 (31.6)

51 (41.5)

2.500

0.114

 Subcutaneous fibrosis

26 (22.2)

29 (23.6)

0.062

0.803

 Xerostomia

68 (58.1)

85 (69.1)

3.132

0.077

 Hear loss

54 (46.2)

64 (52.0)

0.829

0.363

 Temporal lobe injury

4 (3.4)

6 (4.9)

0.059

0.809

  1. Abbreviations as in Table 1