A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma

Table 6 Association of RPMS1 SNP G155391A with the risk of NPC and other malignancies

Region	Sample	Source	155391G & 155391G/A	155391A	OR	P
Guangdong	Healthy subjects^a	TW	743	697	1
	EBV-free tumor^#	TW	24	15	0.67^†	0.257
	NHL^‡	TB	8	5	0.67^†	0.582
	HL	TB	7	3	0.46^†	0.345
	Lymphoma (NHL + HL)	TB	15	8	0.57^†	0.213
	NPC	TB	22	100	8.35^˄	<0.001
Shandong	Healthy subjects^a	TW	578	34	1
	EBVaGC	TB	10	0	0^†	1.000
	NPC	TB	23	13	Inf^˅	0.042

NHL non-Hodgkin’s lymphoma, HL Hodgkin’s lymphoma, EBVaGC EBV-associated gastric carcinoma. Other abbreviations as in Tables 1 and 2
^aHealthy subjects from the discovery and replication stages were combined
^#EBV-free tumors included lung cancer, liver cancer, colorectal cancer, and pancreatic cancer, among others, which were not associated with EBV
^‡NHL included Burkitt’s and NK/T-cell lymphomas
^†The frequency of RPMS1 SNP G155391A in healthy subjects from the same region was considered as a reference, with Fisher’s exact test performed
^˄Lymphoma was considered as a reference
^˅EBVaGC was considered as a reference

ISSN: 2523-3548