A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma

Table 4 Single nucleotide polymorphism (SNP) G155391A of RPMS1 and NPC risk

EBV variant	NPC	Healthy subjects	OR	95% CI	P value
Data_GD1
155391G	28	132	1
G155391A	10	40	1.53	0.66–3.54	0.321
155391A	119	147	4.47	2.71–7.37	<0.001
P ^†_trend					<0.001
Data_GD2
155391G	28	125	1
G155391A	2	5	1.98	0.35–11.33	0.443
155391A	138	111	5.20	3.18–8.50	<0.001
P ^†_trend					<0.001
Data_GD3
155391G	99	357	1
G155391A	12	84	0.61	0.32–1.17	0.136
155391A	615	439	5.27	4.06–6.85	<0.001
P ^†_trend					<0.001
Data_SD
155391G	40	560	1
G155391A	0	18	0	0-Inf	0.987
155391A	18	34	7.52	3.69–15.32	<0.001
P ^†_trend					<0.001
Overall^a
155391G	195	1174	1
G155391A	24	147	0.92	0.56–1.51	0.746
155391A	890	731	5.27	4.31–6.44	<0.001
P ^†_trend					<0.001
I ²			0
P ^‡					0.710

OR odds ratio, 95% CI 95% confidence interval, Inf Infinity. Other abbreviations as in Tables 1 and 2
^aDatasets integrated by meta-analysis
^† P _trend Cochran-Armitage trend test in logistic regression analysis with adjustment for age and gender
^‡ P heterogeneity test among the four datasets

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