The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study

Cancer Communications

Table 1 Associations between T lymphoma invasion and metastasis 1 (Tiam1) expression and clinicopathologic characteristics of the 194 patients with head and neck squamous cell carcinoma (HNSCC)

Characteristic	Tiam1 expression (cases)^a		P value
Characteristic	Low	High	P value
Total	82	112
Age (years)
≤50	29	46	0.836
51–60	27	34
61–70	19	25
>70	7	7
Gender
Male	59	91	0.127
Female	23	21	0.127
Tobacco use
No	38	38	0.080
Yes	44	74	0.080
Alcohol use
No	62	85	0.964
Yes	20	27	0.964
Histological differentiation
Well	48	67	0.289
Moderate	28	30
Poor	6	15
Chronic illness
No	66	90	0.982
Yes	16	22	0.982
T stage
T1/T2	73	90	0.104
T3/T4	9	22	0.104
Lymph node metastasis
No	65	66	0.003
Yes	17	46	0.003
Clinical stage
I/II	62	57	<0.001
III/IV	20	55	<0.001
Tumor position
Oral cavity	71	85	0.064
Buccal mucosa	7	6
Floor of mouth	3	8
Anterior tongue	51	56
Alveolar ridge	10	15
Glottic larynx	8	19
Supraglottic larynx	3	8
Disease recurrence
No	45	33	<0.001
Yes	37	79	<0.001

^aTiam1 expression is scored from 0 to 12. Scores from 0 to 4 indicate low expression; scores of 5 or greater indicate high expression. See the text for details