Table 1 Association of insulin-like growth factor-binding protein-3 (IGFBP-3) expression with clinicopathologic characteristics of ESCC patients
Variable | No. of patients | IGFBP-3 expression [cases (%)] | P valuea | |
|---|---|---|---|---|
High | Low | |||
Ageb | 0.069 | |||
>60 years | 57 | 29 (50.9) | 28 (49.1) | |
≤60 years | 13 | 3 (23.1) | 10 (76.9) | |
Sex | 0.484 | |||
Male | 45 | 20 (44.4) | 25 (55.6) | |
Female | 25 | 12 (48.0) | 13 (52.0) | |
Location | 0.722 | |||
Cervical | 9 | 5 (55.6) | 4 (44.4) | |
Thoracic | 61 | 27 (44.3) | 34 (55.7) | |
Tumor sizec | 0.585 | |||
>6 cm | 22 | 9 (40.9) | 13 (59.1) | |
≤6 cm | 48 | 23 (47.9) | 25 (52.1) | |
T category | 0.003 | |||
T1–2 | 19 | 14 (73.7) | 5 (26.3) | |
T3 | 31 | 14 (45.2) | 17 (54.8) | |
T4 | 20 | 4 (20.0) | 16 (80.0) | |
N category | 0.021 | |||
N0 | 21 | 14 (66.7) | 7 (33.3) | |
N1 | 49 | 18 (36.7) | 31 (63.3) | |
M category | 0.006 | |||
M0 | 50 | 28 (56.0) | 22 (44.0) | |
M1-lymd | 20 | 4 (20.0) | 16 (80.0) | |
Clinical stage | 0.003 | |||
II | 19 | 14 (73.7) | 5 (26.3) | |
III | 31 | 14 (45.2) | 17 (54.8) | |
IV | 20 | 4 (20.0) | 16 (80.0) | |
Survival status | 0.01 | |||
Alive | 20 | 14 (70.0) | 6 (30.0) | |
Dead | 50 | 18 (36.0) | 32 (64.0) | |
Radiotherapy response | <0.001 | |||
Complete reaction | 24 | 20 (83.3) | 4 (16.7) | |
No complete reaction | 46 | 12 (26.1) | 34 (73.9) | |