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Table 1 Association of insulin-like growth factor-binding protein-3 (IGFBP-3) expression with clinicopathologic characteristics of ESCC patients

From: Association of insulin-like growth factor-binding protein-3 with radiotherapy response and prognosis of esophageal squamous cell carcinoma

Variable No. of patients IGFBP-3 expression [cases (%)] P valuea
High Low
Ageb 0.069
 >60 years 57 29 (50.9) 28 (49.1)
 ≤60 years 13 3 (23.1) 10 (76.9)
Sex 0.484
 Male 45 20 (44.4) 25 (55.6)
 Female 25 12 (48.0) 13 (52.0)
Location 0.722
 Cervical 9 5 (55.6) 4 (44.4)
 Thoracic 61 27 (44.3) 34 (55.7)
Tumor sizec 0.585
 >6 cm 22 9 (40.9) 13 (59.1)
 ≤6 cm 48 23 (47.9) 25 (52.1)
T category 0.003
 T1–2 19 14 (73.7) 5 (26.3)
 T3 31 14 (45.2) 17 (54.8)
 T4 20 4 (20.0) 16 (80.0)
N category 0.021
 N0 21 14 (66.7) 7 (33.3)
 N1 49 18 (36.7) 31 (63.3)
M category 0.006
 M0 50 28 (56.0) 22 (44.0)
 M1-lymd 20 4 (20.0) 16 (80.0)
Clinical stage 0.003
 II 19 14 (73.7) 5 (26.3)
 III 31 14 (45.2) 17 (54.8)
 IV 20 4 (20.0) 16 (80.0)
Survival status 0.01
 Alive 20 14 (70.0) 6 (30.0)
 Dead 50 18 (36.0) 32 (64.0)
Radiotherapy response <0.001
 Complete reaction 24 20 (83.3) 4 (16.7)
 No complete reaction 46 12 (26.1) 34 (73.9)
  1. aBy χ2-Test
  2. bMean age
  3. cMean tumor size
  4. dDistant lymph node metastasis