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Table 3 Association between serum levels of CRP-bound SAA (CRP-SAA), total SAA and clinical characteristics of the 464 lung cancer patients

From: The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer

Characteristic CRP-SAA [cases (%)] P value Total SAA [cases (%)] P value
Low level (OD ≤ 0.10) High level (OD > 0.10) Low level (OD ≤ 0.17) High level (OD > 0.17)
Total 212 252   271 193  
Age    0.725    0.741
 <60 years 112 (24.1) 129 (27.8)   139 (30.0) 102 (22.0)  
 ≥60 years 100 (21.6) 123 (26.5)   132 (28.4) 91 (19.6)  
Sex    0.001    0.106
 Male 142 (30.6) 203 (43.8)   194 (41.8) 151 (32.5)  
 Female 70 (15.1) 49 (10.6)   77 (16.6) 42 (9.1)  
Smoking status    <0.001    <0.001
 No 113 (24.4) 85 (18.3)   139 (30.0) 59 (12.7)  
 Yes 99 (21.3) 167 (36.0)   132 (28.4) 134 (28.9)  
Treatment    <0.001    <0.001
 Multimodality therapy without operation 86 (18.5) 54 (11.6)   112 (24.1) 28 (6.0)  
 Operation alone 62 (13.4) 76 (16.4)   82 (17.7) 56 (12.1)  
 Operation and multimodality therapy 64 (13.8) 122 (26.3)   77 (16.6) 109 (23.5)  
T stage    <0.001    <0.001
 T1 41 (8.8) 29 (6.3)   54 (11.6) 16 (3.4)  
 T2 109 (23.5) 100 (21.6)   130 (28.0) 79 (17.0)  
 T3 32 (6.9) 82 (17.7)   51 (11.0) 63 (13.6)  
 T4 30 (6.5) 41 (8.8)   36 (7.8) 35 (7.5)  
N stage    <0.001    <0.001
 N0 93 (20.0) 72 (15.5)   113 (24.4) 52 (11.2)  
 N1 33 (7.1) 41 (8.8)   47 (10.1) 27 (5.8)  
 N2 68 (14.7) 90 (19.4)   84 (18.1) 74 (15.9)  
 N3 18 (3.9) 49 (10.6)   27 (5.8) 40 (8.6)  
M stage    <0.001    <0.001
 M0 174 (37.5) 155 (33.4)   213 (45.9) 116 (25.0)  
 M1 38 (8.2) 97 (20.9)   58 (12.5) 77 (16.6)  
Clinical stage    <0.001    <0.001
 I 57 (12.3) 19 (4.1)   61 (13.1) 15 (3.2)  
 II 41 (8.8) 42 (9.1)   60 (12.9) 23 (5.0)  
 III 76 (16.4) 94 (20.3)   92 (19.8) 78 (16.8)  
 IV 38 (8.2) 97 (20.9)   58 (12.5) 77 (16.6)  
Pathologic type    0.192    0.784
 Adenocarcinoma 112 (24.1) 131 (28.2)   147(31.7) 96(20.7)  
 Squamous cell carcinoma 65 (14.0) 65 (14.0)   72 (15.5) 58 (12.5)  
 Small cell carcinoma 15 (3.2) 33 (7.1)   26 (5.6) 22 (4.7)  
 Others 20 (4.3) 23 (5.0)   26 (5.6) 17 (3.7)  
Primary tumor site    0.821    0.301
 Left lung 86 (18.5) 107 (23.1)   105 (22.6) 88 (19.0)  
 Right lung 126 (27.2) 145 (31.3)   166 (35.8) 105 (22.6)  
  1. The Mann-Whitney U test was used to analyze the associations. Tumor size, lymph node involvement, distant metastasis, and clinical stage were classified according to the seventh edition of the Union for International Cancer Control (UICC) Staging system for Lung Cancer.
  2. P < 0.05 is considered significant and the P-value is in italics.
  3. OD optical density.