Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

Zeng, Meiqi; Zheng, Manyin; Lu, Desheng; Wang, Jun; Jiang, Wenqi; Sha, Ou

doi:10.1186/s40880-015-0030-x

Cancer Communications

Table 1 Anti-tumor activities of various ribosome-inactivating proteins (RIPs)

From: Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

RIP	Tumor type	Tested cell line(s)
Type I
Trichosanthin	Breast cancer	MDA-MB-231^a and MCF-7 [5]
	Lymphoma	CEM, Hut-78, Raji, and Daudi [12]
	Cervical cancer	HeLa [37]; Caski [38]
	Choriocarcinoma	JAR and BeWo [39]
	Colon cancer	CT-26 [40]; LoVo [41]
	Hepatoma	HepG2 [42]
	Leukemia	Molt-4 and Jurkat [12]; K562 [43]
	Lung cancer	3LL^a [44]
	Melanoma	B16 [45]
	Nasopharyngeal cancer	CNE1^a and CNE2^a [46]; CNE2 [47]
	Prostate cancer	RM-1 [48]
	Gastric cancer	MCG803 [49]
α-Momorcharin	Breast cancer	MCF-7, EMT-6^a, and MDA-MB-231^a [11]
	Colon cancer	SW480 and SW620 [50]
	Epidermoid	A431 and Hep-2 [50]
	Hepatoma	Hep G2 and SMMC-7721 [50]
	Lung cancer	NCI-H460 and A549 [50]
	Melanoma	B16, M14, SK-MEL-28, and A2058 [50]
	Nasopharyngeal cancer	CNE2 and HONE1 [51]
Momordica anti-HIV protein of 30 kDa	Bladder cancer	5637 [52]
	Breast cancer	MDA-MB-231^a [6]; BT20 [53]; MCF-7 [54]
	Epidermoid	A431 [53]
	Glioma	U87MG [53]
	Hepatoma	Hep G2^a [27]; Hep-3B [53]
	Melanoma	Malme-3M [53]
	Myeloma	U266 [53]
	Neuroblastoma	SK-N-SH [53]
	Prostate cancer	DU145 [53]
	Lung cancer	A549 [55]
Cucurmosin	Lung cancer	A549 [13]
	Melanoma	B16 [13]
	Hepatoma	HepG2^a [28]
	Leukemia	NB4 [14]; K562^a [56]
	Myeloma	RPM18226 [57]
	Pancreatic cancer	BxPC-3 [58]; SW-1990 [59]; PANC-1^a [60]; CFPAC-1 [61]
Saporin	Leukemia	NALM-6^a [22]; HSB-2^a [23]; CCRF CEM^a [24]
	Glioma	U87MG [62]
	Lymphoma	Ramos, Raji^a, Daudi, DOHH-2, and Granta 519, SUDHL-4 [21]; HDLM2, KM/H2, and L428 [63]
	Neuroblastoma	SK-N-MC^a [64]
	Ovarian cancer	PA-1^a [64]
	Melanoma	SK-Mel-1^a [64], SK-Mel-28 [65]
	Pancreatic cancer	BxPC-3^a [66]
	Prostate cancer	LNCaP^a, CWR22Rv1, and DU145 [67]; PC-3^a [68]
Gelonin	Breast cancer	MDA-MB-231^a, BT-474, SKBR3, MCF-7, and Eb1 [8]
	Melanoma	MDA-MB-435^a, WM35, WM46, WM3211, WM1346, WM1361A, WM1366, WM793, WM983A, WM983B, MeWo, SB2, A375, A375M, SK-MEL-1, SK-MEL-3, SK-MEL-5, SK-MEL-24, SK-MEL-28, SK-MEL-32, WM35P2N1, AAB-527, and Sbcl2 [18]
	Cervical cancer	ME-180 [69]
	Ovarian cancer	SKOV3 [69]
	Pancreatic cancer	Capan-1, Capan-2, MIA-PaCa-2, AsPC-1, BxPC-3, and L3.6P1 [69]
	Sarcoma	HT-1080 [69]
	Gastric cancer	NCI N-87 [69]
	Bladder cancer	T-24^a [69]; RT112^a [70]
	Epidermoid	A431 [71]
	Glioma	U87 MG [69]; 9L [72]
	Prostate cancer	PC-3 [72]
	Colon cancer	HT-29^a [71]; CT26^a and LS174T [72]
	Leukemia	NALM-6^a [25]; HL-60 [73]
	Lung cancer	Calu-3 [69]; A549^a, H1975, and HCC827 [74]
	Lymphoma	Rec-1^a and NUDHL-1^a [25]; Mino^a, JeKo-1, SP53 [26]; OCI-Ly3, OCI-Ly10^a, SUDHL-4, and SUDHL-6 [75]
Marmorin	Breast cancer	MCF-7^a and MDA-MB-231^a [10]
α-Sarcin	Astrocytoma	251-MG [76]
	Breast cancer	MCF-7 [76]
	Glioma	RuGli [76]
	Pancreatic cancer	Patu II [76]
	Bladder cancer	EJ [77]
	Colon cancer	HT29 and BCS-TC2 [76]; SW1222 [78]
	Sarcoma	HT-1080 [76]; S-180 [79]; RD [80]
Curcin	Lung cancer	NCL-H446 [81]
	Gastric cancer	SGC-7901 [81]
	Sarcoma	S-180 [82]
α-Luffin	Breast cancer	MCF-7 [83]
	Choriocarcinoma	JEG-3 [83]
	Hepatoma	HepG2 [83]
MCP30	Prostate cancer	LNCaP, PC-3, and PIN [84]
Gelonium anti-HIV protein of 31 kDa	Breast cancer	MDA-MB-231^a [6]
Type II
Riproximin	Breast cancer	MCF-7 and MDA-MB-231 [62]
	Larynx cancer	Hep2 [62]
	Leukemia	AR230, CML-T1, HL-60, LAMA84, SKW-3, K562, and BV173 [62]
	Lung cancer	NCI-H460 and Lewis^a [62]
	Pancreatic cancer	ASML^b [62]
	Prostate cancer	PC-3 [62]
	Sarcoma	Saos-2 [62]
	Cervical cancer	KB-3-1^a [62]; HeLa [85]
	Colon cancer	HT-29, CC531^b, and CT-26^a [62]; HCT116 [86]
Abrus agglutinin	Hepatoma	HepG2^a [29]
Momordica charantia lectin	Nasopharyngeal cancer	CNE1 and CNE2 [35]
Articulatin-D	Leukemia	Jurkat, Molt-4, and HL-60 [15]
Articulatin-D	Lymphoma	U937 and Raji [15]
Mistletoe lectin I	Leukemia	NALM-6 [87]
Foetidissimin II	Cervical cancer	HeLa [88]
Foetidissimin II	Leukemia	TF-1a [88]
Ebulin I & Nigrin b	Cervical cancer	HeLa [89]

^aCell lines that have been studied in mouse.
^bCell lines that have been studied in rat.

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