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Table 4 The relationship between clinical characteristics and overall survival in HCC patients based on the stratification with the TNM staging system: Cox’s regression analysis

From: Impact of oral anti–hepatitis B therapy on the survival of patients with hepatocellular carcinoma initially treated with chemoembolization

Variable   TNM early stage ( n  = 71)   TNM advanced stage ( n  = 153)
Univariate analysis   Multivariate analysis   Univariate analysis   Multivariate analysis
P value   Hazard ratio 95% CI P value   P value   Hazard ratio 95% CI P value
Age   0.821   1.001 0.978–1.025 0.920   0.075   0.975 0.956–0.995 0.016
Sex   0.158   3.946 1.332–11.690 0.013   0.372   1.891 0.641–5.577 0.248
HBV DNA (log 10 IU/mL)   0.408    0.328  
ALT   0.445    0.994  
Cycles of TACE   0.885    0.070   1.305 0.836–2.037 0.242
AST   0.016   1.004 0.996–1.012 0.363   0.001   1.002 0.999–1.005 0.201
ALB   0.149    0.066   0.945 0.893–1.000 0.051
TBIL   0.711    0.024   1.008 0.982–1.035 0.555
AFP   0.022   2.087 0.920–4.736 0.078   0.067   1.144 0.741–1.767 0.545
APTT   0.709    0.068   0.988 0.942–1.037 0.633
Antiviral treatment   0.012   0.372 0.183–0.756 0.006   0.219  
Local ablation   0.005   0.280 0.136–0.577 0.001   <0.001   0.211 0.095–0.472 <0.001
Resection   0.023   0.152 0.049–0.473 0.001   0.008   0.308 0.118–0.801 0.016
HBeAg   0.958    0.621  
PT   0.241    0.765  
Sorafenib therapy   0.943    0.782  
Chemotherapeutic agents
(epirubicin only: >2 agents)
  0.211    0.073   0.881 0.540–1.439 0.613
  1. Abbreviations as in Table 1.