Cytotoxicity of paclitaxel and cabazitaxel in ABCB1- and ABCC10-overexpressing cells. ABCB1, ATP-binding cassette subfamily B member 1; ABCC10, ATP-binding cassette subfamily C member 10. The cytotoxicity of paclitaxel and cabazitaxel was determined by the MTT assay in ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells, ABCC10-overexpressing HEK293/ABCC10 cells, and their parental KB-3-1, LLC-PK1, and HEK293/pcDNA3.1 cells. Error bars indicate the standard deviation (SD). Significantly elevated resistance of KB-C2 (A) and LLC-MDR1-WT cells (C) to paclitaxel, none or low-level resistance of KB-C2 (B) and LLC-MDR1-WT cells (D) to cabazitaxel, significantly elevated resistance of HEK293/ABCC10 cells to paclitaxel (E), and no resistance of HEK293/ABCC10 cells to cabazitaxel (F) are observed as compared with those of their parental cells.