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  1. Toxic epidermal necrolysis (TEN) is a rare acute life-threatening mucocutaneous disorder that is mostly drug-related (80%–95%). It is clinically characterized as a widespread sloughing of the skin and mucosa. ...

    Authors: Ji-Jie Huang, Shu-Xiang Ma, Xue Hou, Zhao Wang, Yin-Duo Zeng, Tao Qin, Xiao-Xiao Dinglin and Li-Kun Chen
    Citation: Chinese Journal of Cancer 2015 34:340020094
  2. For children with stage II testicular malignant germ cell tumors (MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there...

    Authors: Su-Ying Lu, Xiao-Fei Sun, Zi-Jun Zhen, Zi-Ke Qin, Zhuo-Wei Liu, Jia Zhu, Juan Wang and Fei-Fei Sun
    Citation: Chinese Journal of Cancer 2015 34:340020086
  3. The time to complete or partial (objective) response to radiotherapy in patients with hepatocellular carcinoma (HCC) is variable; thus, the reported frequency of these responses depends on the length of follow...

    Authors: Moonkyoo Kong and Seong Eon Hong
    Citation: Chinese Journal of Cancer 2015 34:340020079
  4. Interim 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (I-PET/CT) is a powerful tool for monitoring the response to therapy in diffuse large B-cell lymphoma (DLBCL). This retrospect...

    Authors: Xu Zhang, Wei Fan, Zhong-Jun Xia, Ying-Ying Hu, Xiao-Ping Lin, Ya-Rui Zhang, Zhi-Ming Li, Pei-Yan Liang and Yuan-Hua Li
    Citation: Chinese Journal of Cancer 2015 34:340020070
  5. Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion...

    Authors: Yu Du and Jennifer R. Grandis
    Citation: Chinese Journal of Cancer 2015 34:340020061
  6. Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a ne...

    Authors: Cristina Sigismondi, Enrico Papaleo, Paola Viganò, Simona Vailati, Massimo Candiani, Jessica Ottolina, Valentina E. Di Mattei and Giorgia Mangili
    Citation: Chinese Journal of Cancer 2015 34:340010056
  7. Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cor...

    Authors: Mojgan Devouassoux-Shisheboran and Catherine Genestie
    Citation: Chinese Journal of Cancer 2015 34:340010050
  8. Epithelial ovarian cancer (OC) is a common gynecologic malignancy in women. The standard treatment for OC is maximal cytoreductive surgical debulking followed by platinum-based chemotherapy. Despite the high r...

    Authors: José Antonio López-Guerrero, Ignacio Romero and Andrés Poveda
    Citation: Chinese Journal of Cancer 2015 34:340010041
  9. Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition (EMT), during which cells dedifferentiate from a...

    Authors: Yan Sun, Fei Guo, Marina Bagnoli, Feng-Xia Xue, Bao-Cun Sun, Ilya Shmulevich, Delia Mezzanzanica, Ke-Xin Chen, Anil K. Sood, Da Yang and Wei Zhang
    Citation: Chinese Journal of Cancer 2015 34:340010028
  10. Ovarian cancer remains a major issue for gynecological oncologists, and most patients are diagnosed when the disease is already advanced with a poor chance of survival. Debulking surgery followed by platinum-t...

    Authors: Chiara Della Pepa, Giuseppe Tonini, Carmela Pisano, Marilena Di Napoli, Sabrina Chiara Cecere, Rosa Tambaro, Gaetano Facchini and Sando Pignata
    Citation: Chinese Journal of Cancer 2015 34:340010017
  11. In this issue of the Chinese Journal of Cancer, European, American, and Chinese experts review the current management and future perspectives of epithelial ovarian cancer (EOC), the leading cause of gynecological...

    Authors: Delia Mezzanzanica
    Citation: Chinese Journal of Cancer 2015 34:340010001
  12. Multimodality therapy, including preoperative chemoradiotherapy (CRT) and total mesorectal excision (TME), has effectively reduced local recurrence rates of rectal cancer over the past decade. However, the ben...

    Authors: Wen-Hua Fan, Fu-Long Wang, Zhen-Hai Lu, Zhi-Zhong Pan, Li-Ren Li, Yuan-Hong Gao, Gong Chen, Xiao-Jun Wu, Pei-Rong Ding, Zhi-Fan Zeng and De-Sen Wan
    Citation: Chinese Journal of Cancer 2015 34:25
  13. Right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) differ with respect to their biology and genomic patterns. This study aimed to examine whether the primary tumor location is associated ...

    Authors: Feng Wang, Long Bai, Tian-Shu Liu, Yi-Yi Yu, Ming-Ming He, Kai-Yan Liu, Hui-Yan Luo, Dong-Sheng Zhang, Yin Jin, Feng-Hua Wang, Zhi-Qiang Wang, De-Shen Wang, Miao-Zhen Qiu, Chao Ren, Yu-Hong Li and Rui-Hua Xu
    Citation: Chinese Journal of Cancer 2015 34:24
  14. Patients with metastatic nasopharyngeal carcinoma (NPC) have variable survival outcomes. We have previously shown that an elevated peripheral blood lymphocyte-to-monocyte ratio (LMR) is associated with an incr...

    Authors: Rou Jiang, Xiu-Yu Cai, Zhong-Han Yang, Yue Yan, Xiong Zou, Ling Guo, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Pei-Yu Huang, Yan-Qun Xiang, Xing Lu, Lin Wang, Wei-Xiong Xia, Hai-Qiang Mai and Ming-Yuan Chen
    Citation: Chinese Journal of Cancer 2015 34:23
  15. Transcatheter arterial chemoembolization (TACE) plus thermal ablation has been widely used recently in the treatment of hepatocellular carcinoma (HCC). In this study, we aimed to compare results of the combina...

    Authors: Sheng Li, Liang Zhang, Zhi-Mei Huang and Pei-Hong Wu
    Citation: Chinese Journal of Cancer 2015 34:22
  16. The properties of a tumor itself were considered the main factors determining the survival of patients with locally recurrent nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT)...

    Authors: Yun-Ming Tian, Wei-Wei Xiao, Li Bai, Xue-Wen Liu, Chong Zhao, Tai-Xiang Lu and Fei Han
    Citation: Chinese Journal of Cancer 2015 34:21
  17. Fluorine-18 fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) is a powerful tool for monitoring the response of diffuse large B-cell lymphoma (DLBCL) to therapy, but the crit...

    Authors: Xu Zhang, Wei Fan, Ying-Ying Hu, Zhi-Ming Li, Zhong-Jun Xia, Xiao-Ping Lin, Ya-Rui Zhang, Pei-Yan Liang and Yuan-Hua Li
    Citation: Chinese Journal of Cancer 2015 34:20
  18. Hepatitis B virus (HBV) reactivation has been reported in B-cell lymphoma patients with resolved hepatitis B (hepatitis B surface antigen [HBsAg]-negative and hepatitis B core antibody [HBcAb]-positive). This ...

    Authors: Kai-Lin Chen, Jie Chen, Hui-Lan Rao, Ying Guo, Hui-Qiang Huang, Liang Zhang, Jian-Yong Shao, Tong-Yu Lin, Wen-Qi Jiang, De-Hui Zou, Li-Yang Hu, Michael Lucas Wirian and Qing-Qing Cai
    Citation: Chinese Journal of Cancer 2015 34:18
  19. Hepatocellular adenomas (HCAs), with a risk of malignant transformation into hepatocellular carcinoma (HCC), classically develop in young women who are taking oral contraceptives. It is now clear that HCAs may...

    Authors: Song-Lin An, Li-Ming Wang, Wei-Qi Rong, Fan Wu, Wei Sun, Wei-Bo Yu, Li Feng, Fa-Qiang Liu, Fei Tian and Jian-Xiong Wu
    Citation: Chinese Journal of Cancer 2015 34:17
  20. It is important to decrease the radiation exposure of normal tissue in intensity-modulated radiation therapy (IMRT). Minimizing planning target volume (PTV) margins with more precise target localization techni...

    Authors: Yan-Ping Mao, Wen-Jing Yin, Rui Guo, Guang-Shun Zhang, Jian-Lan Fang, Feng Chi, Zhen-Yu Qi, Meng-Zhong Liu, Jun Ma and Ying Sun
    Citation: Chinese Journal of Cancer 2015 34:16
  21. In the past several decades, declining incidences of nasopharyngeal carcinoma (NPC) have been observed in Chinese populations in Hong Kong, Taiwan, Los Angeles, and Singapore. A previous study indicated that t...

    Authors: Li-Fang Zhang, Yan-Hua Li, Shang-Hang Xie, Wei Ling, Sui-Hong Chen, Qing Liu, Qi-Hong Huang and Su-Mei Cao
    Citation: Chinese Journal of Cancer 2015 34:15
  22. Most hepatocellular carcinomas (HCC) develop in a background of underlying liver disease including chronic hepatitis B. However, the effect of antiviral therapy on the long-term outcome of patients with hepati...

    Authors: Zhong-Guo Zhou, Xing-Rong Zheng, Qian Zhou, Ming Shi, Yao-Jun Zhang, Rong-Ping Guo, Yun-Fei Yuan, Min-Shan Chen, Xiao-Jun Lin, Xiang-Ming Lao and Sheng-Ping Li
    Citation: Chinese Journal of Cancer 2015 34:14
  23. Breast cancer is a leading tumor with a high mortality in women. This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012.

    Authors: Hai-Bin Zhou, Sheng-Yuan Liu, Lin Lei, Zhong-Wei Chen, Ji Peng, Ying-Zhou Yang and Xiao-Li Liu
    Citation: Chinese Journal of Cancer 2015 34:13
  24. An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma (NPC). However, targeted therapy-related oncogenic mutations have not been fully evaluated. This study aime...

    Authors: Jian-Wei Zhang, Tao Qin, Shao-Dong Hong, Jing Zhang, Wen-Feng Fang, Yuan-Yuan Zhao, Yun-Peng Yang, Cong Xue, Yan Huang, Hong-Yuan Zhao, Yu-Xiang Ma, Zhi-Huang Hu, Pei-Yu Huang and Li Zhang
    Citation: Chinese Journal of Cancer 2015 34:10
  25. Oncogenic activation of the K-ras gene occurs in >90% of pancreatic ductal carcinoma and plays a critical role in the pathogenesis of this malignancy. Increase of reactive oxygen species (ROS) has also been obser...

    Authors: Peng Wang, Yi-Chen Sun, Wen-Hua Lu, Peng Huang and Yumin Hu
    Citation: Chinese Journal of Cancer 2015 34:8
  26. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances...

    Authors: Rishil J Kathawala, Yi-Jun Wang, Suneet Shukla, Yun-Kai Zhang, Saeed Alqahtani, Amal Kaddoumi, Suresh V Ambudkar, Charles R Ashby Jr and Zhe-Sheng Chen
    Citation: Chinese Journal of Cancer 2015 34:5
  27. Patients with nasopharyngeal carcinoma (NPC) sporadically develop abnormal adenoids. Nasopharyngeal adenoids are usually included in the gross tumor volume (GTV) but may have different therapeutic responses th...

    Authors: Yao-Pan Wu, Pei-Qiang Cai, Li Tian, Jie-Hua Xu, Richard Alan Mitteer Jr, Yi Fan and Zhenfeng Zhang
    Citation: Chinese Journal of Cancer 2015 34:4
  28. In the adult human breast, hyperplastic enlarged lobular unit (HELU) and atypical ductal hyperplasia (ADH) are two common abnormalities that frequently coexist with ductal carcinoma in situ (DCIS). For this reaso...

    Authors: Danila Coradini, Patrizia Boracchi, Saro Oriana, Elia Biganzoli and Federico Ambrogi
    Citation: Chinese Journal of Cancer 2015 34:3
  29. Polymorphisms in DNA repair genes may alter DNA repair capacity and, consequently, lead to genetic instability and carcinogenesis. Several studies have investigated the association of the Asp312Asn and Lys751G...

    Authors: Shen Chen, Jin-Hong Zhu, Fang Wang, Shao-Yi Huang, Wen-Qiong Xue, Zhuo Cui, Jing He and Wei-Hua Jia
    Citation: Chinese Journal of Cancer 2015 34:2
  30. Thrombocytosis has been identified as an unfavorable prognostic factor in several types of cancer. This study aimed to evaluate the prognostic value of pretreatment platelet count in association with the TNM s...

    Authors: Yu-Pei Chen, Bing-Cheng Zhao, Chen Chen, Lu-Jun Shen, Jin Gao, Zhuo-Yao Mai, Meng-Kun Chen, Gang Chen, Fang Yan, Su Liu and Yun-Fei Xia
    Citation: Chinese Journal of Cancer 2015 34:1