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  1. Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy. Although several discoveri...

    Authors: Mengying Tong, Ziqian Deng, Mengying Yang, Chang Xu, Xiaolong Zhang, Qingzheng Zhang, Yuwei Liao, Xiaodi Deng, Dekang Lv, Xuehong Zhang, Yu Zhang, Peiying Li, Luyao Song, Bicheng Wang, Aisha Al-Dherasi, Zhiguang Li…
    Citation: Cancer Communications 2018 38:56
  2. The tumor–node–metastasis (TNM) staging system does not perform well for guiding individualized induction or adjuvant chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We a...

    Authors: Pu-Yun OuYang, Kai-Yun You, Lu-Ning Zhang, Yao Xiao, Xiao-Min Zhang and Fang-Yun Xie
    Citation: Cancer Communications 2018 38:55
  3. Treatment guidelines for a variety of cancers have been increasingly used in clinical practice, and have resulted in major improvement in patient outcomes. However, recommended regimens (even first-line treatm...

    Authors: Peng Zhao, Hui Chen, Danyi Wen, Shuo Mou, Feifei Zhang and Shusen Zheng
    Citation: Cancer Communications 2018 38:54
  4. We previously found that overexpression of the gene known as amplified in breast cancer 1 (AIB1) was associated with lymph node metastasis and poor prognosis in patients with lung adenocarcinoma. However, the rol...

    Authors: Liru He, Haixia Deng, Shiliang Liu, Jiewei Chen, Binkui Li, Chenyuan Wang, Xin Wang, Yiguo Jiang, Ningfang Ma, Mengzhong Liu and Dan Xie
    Citation: Cancer Communications 2018 38:53
  5. The antitumour efficacy of tyrosine kinase inhibitors (TKIs) in lung cancer patients with compound epidermal growth factor receptor (EGFR) mutations has not been resolved. Our study summarizes a single institutio...

    Authors: Xiangyang Yu, Xuewen Zhang, Zichen Zhang, Yongbin Lin, Yingsheng Wen, Yongqiang Chen, Weidong Wang and Lanjun Zhang
    Citation: Cancer Communications 2018 38:51
  6. In previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or ...

    Authors: Yanjun Huang, Sichun Zhou, Caimei He, Jun Deng, Ting Tao, Qiongli Su, Kwame Oteng Darko, Mei Peng and Xiaoping Yang
    Citation: Cancer Communications 2018 38:50
  7. Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) share many common features, including similar morphology, gene expression and in vitro differentiation profiles. However, genomic stabilit...

    Authors: Minjie Zhang, Liu Wang, Ke An, Jun Cai, Guochao Li, Caiyun Yang, Huixian Liu, Fengxia Du, Xiao Han, Zilong Zhang, Zitong Zhao, Duanqing Pei, Yuan Long, Xin Xie, Qi Zhou and Yingli Sun
    Citation: Cancer Communications 2018 38:49
  8. Gallbladder carcinoma is highly aggressive and resistant to chemotherapy, with no consistent strategy to guide first line chemotherapy. However, patient-derived xenograft (PDX) model has been increasingly used...

    Authors: Ming Zhan, Rui-meng Yang, Hui Wang, Min He, Wei Chen, Sun-wang Xu, Lin-hua Yang, Qiang Liu, Man-mei Long and Jian Wang
    Citation: Cancer Communications 2018 38:48
  9. It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host tissue. Therefore we e...

    Authors: Edina Bugyik, Vanessza Szabó, Katalin Dezső, András Rókusz, Armanda Szücs, Péter Nagy, József Tóvári, Viktória László, Balázs Döme and Sándor Paku
    Citation: Cancer Communications 2018 38:46
  10. Gastric cancer (GC) is one of the most common malignancies worldwide, particularly in China. DNA damage-inducible transcript 4 (DDIT4) is a mammalian target of rapamycin inhibitor and is induced by various cel...

    Authors: Feng Du, Lina Sun, Yi Chu, Tingyu Li, Chao Lei, Xin Wang, Mingzuo Jiang, Yali Min, Yuanyuan Lu, Xiaodi Zhao, Yongzhan Nie and Daiming Fan
    Citation: Cancer Communications 2018 38:45
  11. The relationship between cancer and life expectancy is well established in both developed and developing countries. China is a vast country with significant geographical differences in population structure and...

    Authors: Xiuying Gu, Rongshou Zheng, Changfa Xia, Hongmei Zeng, Siwei Zhang, Xiaonong Zou, Zhixun Yang, He Li and Wanqing Chen
    Citation: Cancer Communications 2018 38:44
  12. Azithromycin is a member of macrolide antibiotics, and has been reported to inhibit the proliferation of cancer cells. However, the underlying mechanisms are not been fully elucidated. Tumor necrosis factor-re...

    Authors: Xinran Qiao, Xiaofei Wang, Yue Shang, Yi Li and Shu-zhen Chen
    Citation: Cancer Communications 2018 38:43
  13. Hepatocellular carcinoma (HCC) is one of the most frequent causes of cancer-related death. Sorafenib, a multitarget angiogenesis inhibitor, is an approved frontline treatment for advanced HCC in Western countr...

    Authors: Giovanni Brandi, Michela Venturi, Stefania De Lorenzo, Francesca Garuti, Giorgio Frega, Andrea Palloni, Ingrid Garajovà, Francesca Abbati, Gioconda Saccoccio, Rita Golfieri, Maria Abbondanza Pantaleo and Maria Aurelia Barbera
    Citation: Cancer Communications 2018 38:41
  14. Asians are diagnosed with breast cancer at a younger age than Caucasians are. We studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conser...

    Authors: Fuh Yong Wong, Wei Ying Tham, Wen Long Nei, Cindy Lim and Hui Miao
    Citation: Cancer Communications 2018 38:39
  15. Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease (EMPD) of the genital region is wide surgical excision of the lesion, the procedure is highly invasive and can lea...

    Authors: Junichi Hiratsuka, Nobuhiko Kamitani, Ryo Tanaka, Eisaku Yoden, Ryuji Tokiya, Minoru Suzuki, Rolf F. Barth and Koji Ono
    Citation: Cancer Communications 2018 38:38
  16. Head and neck (HN) cancer is an endemic disease in Taiwan, China. Locally recurrent HN cancer after full-dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a soluti...

    Authors: Ling-Wei Wang, Yen-Wan Hsueh Liu, Fong-In Chou and Shiang-Huei Jiang
    Citation: Cancer Communications 2018 38:37
  17. Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produc...

    Authors: Rolf F. Barth, Peng Mi and Weilian Yang
    Citation: Cancer Communications 2018 38:35
  18. Following publication of the results of the National Lung Screening Trial in the United States, a randomized controlled trial in Italy (ITALUNG) and two simulation studies in China reported similar findings in...

    Authors: Zixing Wang, Yuyan Wang, Yao Huang, Fang Xue, Wei Han, Yaoda Hu, Lei Wang, Wei Song and Jingmei Jiang
    Citation: Cancer Communications 2018 38:34
  19. Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma (ESCC). NS1-binding protein (NS1-BP), a member of the BTB-kelch protein family,...

    Authors: Yuwen Wang, Jingjing Cheng, Dan Xie, Xiaofeng Ding, Hailing Hou, Xi Chen, Puchun Er, Furong Zhang, Lujun Zhao, Zhiyong Yuan, Qingsong Pang, Ping Wang and Dong Qian
    Citation: Cancer Communications 2018 38:33
  20. Combination therapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) chemotherapy drastically improves survival of advanced pancreatic cancer patients. However, the efficacy of FOLFIRINO...

    Authors: Jung Hoon Kim, Sang-Cheol Lee, Sung Yong Oh, Seo-Young Song, Namsu Lee, Eun Mi Nam, Soonil Lee, In Gyu Hwang, Hyo Rak Lee, Kyu Taek Lee, Sang-Byung Bae, Han Jo Kim, Joung Soon Jang, Do Hyoung Lim, Hyun Woo Lee, Seok Yun Kang…
    Citation: Cancer Communications 2018 38:32
  21. Patients with relapsed/refractory B-cell lymphomas have limited treatment options. GERSHWIN is an open-label, single-arm, phase Ib study of obinutuzumab monotherapy in Chinese patients with histologically docu...

    Authors: Yan Qin, Yuqin Song, Zhixiang Shen, Xin Du, Wei Ji, Wanling Hsu, Jun Zhu and Yuankai Shi
    Citation: Cancer Communications 2018 38:31
  22. Spontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis. However, approximately 30% of MCL patients c...

    Authors: Haige Ye, Aakash Desai, Tiejun Gong, Dongfeng Zeng, Krystle Nomie, Wendy Chen, Wei Wang, Jorge Romaguera and Michael L. Wang
    Citation: Cancer Communications 2018 38:30
  23. Although colorectal oligometastases to the liver can potentially be cured with aggressive local ablation, the efficacy of adjuvant chemotherapy (ACT) for such metastasis remains unclear. The present study expl...

    Authors: Zhizhong Pan, Jianhong Peng, Junzhong Lin, Gong Chen, Xiaojun Wu, Zhenhai Lu, Yuxiang Deng, Yujie Zhao, Qiaoqi Sui and Desen Wan
    Citation: Cancer Communications 2018 38:29
  24. Plasma circulating tumor DNA (ctDNA) is an ideal approach to detecting the epidermal growth factor receptor (EGFR) T790M mutation, which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase...

    Authors: Shirong Zhang, Lucheng Zhu, Bing Xia, Enguo Chen, Qiong Zhao, Xiaochen Zhang, Xueqin Chen, Xufeng Chen and Shenglin Ma
    Citation: Cancer Communications 2018 38:28
  25. Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma (HCC) resection because of limited evidence regarding the optimal interval. We aimed to compare the associations o...

    Authors: Wei He, Yun Zheng, Ruhai Zou, Jingxian Shen, Junping Yang, Jiliang Qiu, Qiang Tao, Wenwu Liu, Zhiwen Yang, Yuanping Zhang, Binkui Li and Yunfei Yuan
    Citation: Cancer Communications 2018 38:26
  26. Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression. Cancer-induced metabolic changes alter th...

    Authors: Yi-Ping Wang and Qun-Ying Lei
    Citation: Cancer Communications 2018 38:25
  27. Neoadjuvant chemoradiotherapy followed by surgery is recommended as the standard of care for locally advanced rectal cancer, reducing local recurrence but not distant metastasis. Intensified systemic therapy i...

    Authors: Xin Yu, Qiao-xuan Wang, Wei-wei Xiao, Hui Chang, Zhi-fan Zeng, Zhen-hai Lu, Xiao-jun Wu, Gong Chen, Zhi-zhong Pan, De-sen Wan, Pei-rong Ding and Yuan-hong Gao
    Citation: Cancer Communications 2018 38:24
  28. Few studies have shown nomograms that may predict disease-specific survival (DSS) probability after curative D2 gastrectomy for advanced gastric cancer (AGC), particularly among Chinese patients. This study so...

    Authors: Wei Wang, Zhe Sun, Jing-Yu Deng, Xiao-Long Qi, Xing-Yu Feng, Cheng Fang, Xing-Hua Ma, Zhen-Ning Wang, Han Liang, Hui-Mian Xu and Zhi-Wei Zhou
    Citation: Cancer Communications 2018 38:23
  29. 5-Fluorouracil (5-FU) and capecitabine-associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but ...

    Authors: Jianjun Peng, Chao Dong, Chang Wang, Weihua Li, Hao Yu, Min Zhang, Qun Zhao, Bo Zhu, Jun Zhang, Wenliang Li, Fenghua Wang, Qiong Wu, Wenhao Zhou, Ying Yuan, Meng Qiu and Gong Chen
    Citation: Cancer Communications 2018 38:22
  30. Available data in the literature comparing different induction chemotherapy (IC) regimens on locoregionally advanced nasopharyngeal carcinoma (NPC) are scarce. The purpose of the present study was to evaluate ...

    Authors: Guo-Ying Liu, Xing Lv, Yi-Shan Wu, Min-Jie Mao, Yan-Fang Ye, Ya-Hui Yu, Hu Liang, Jing Yang, Liang-Ru Ke, Wen-Ze Qiu, Xin-Jun Huang, Wang-Zhong Li, Xiang Guo, Yan-Qun Xiang and Wei-Xiong Xia
    Citation: Cancer Communications 2018 38:21
  31. Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the patholog...

    Authors: Long-Jun He, Chuanbo Xie, Yin Li, Lin-Na Luo, Ke Pan, Xiao-Yan Gao, Li-Zhi Liu, Jian-Ming Gao, Guang-Yu Luo, Hong-Bo Shan, Ming-Yuan Chen, Chong Zhao, Wei-Jun Fan, Ping Yang, Guo-Liang Xu and Jian-Jun Li
    Citation: Cancer Communications 2018 38:20
  32. Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions show dramatic responses to specific tyrosine kinase inhibitors (TKIs)...

    Authors: Yunhua Xu, Feifei Zhang, Xiaoqing Pan, Guan Wang, Lei Zhu, Jie Zhang, Danyi Wen and Shun Lu
    Citation: Cancer Communications 2018 38:19
  33. Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial–mesenchymal transition and tumorigenesis. The present ...

    Authors: Hailu Fu, Huijun Gao, Xiaoyu Qi, Lei Zhao, Donghua Wu, Yuxin Bai, Huimin Li, Xuan Liu, Jun Hu and Shujuan Shao
    Citation: Cancer Communications 2018 38:18
  34. Precision medicine has shed new light on the treatment of heterogeneous cancer patients. However, intratumor heterogeneity strongly constrains the clinical benefit of precision medicine. Thus, rethinking thera...

    Authors: Mengying Tong, Ziqian Deng, Xiaolong Zhang, Bin He, Mengying Yang, Wei Cheng and Quentin Liu
    Citation: Cancer Communications 2018 38:17
  35. Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia-inducible...

    Authors: Yan Huang, Ying Tian, Yuanyuan Zhao, Cong Xue, Jianhua Zhan, Lin Liu, Xiaobo He and Li Zhang
    Citation: Cancer Communications 2018 38:15
  36. The association between type 2 diabetes mellitus (T2DM) and the risk of esophageal cancer remains unclear. The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival i...

    Authors: Wang Yao, Yuqi Meng, Mingjian Lu, Wenzhe Fan, Jinhua Huang, Jiaping Li and Zhihua Zhu
    Citation: Cancer Communications 2018 38:14
  37. Pancreatic duct adenocarcinoma (PDAC) remains a major health problem because conventional cancer treatments are relatively ineffective against it. Microarray studies have linked many genes to pancreatic cancer...

    Authors: Jun Li, Wenle Tan, Linna Peng, Jialiang Zhang, Xudong Huang, Qionghua Cui, Jian Zheng, Wen Tan, Chen Wu and Dongxin Lin
    Citation: Cancer Communications 2018 38:13
  38. Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human...

    Authors: Pranavi Koppula, Yilei Zhang, Li Zhuang and Boyi Gan
    Citation: Cancer Communications 2018 38:12
  39. Technical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal sparing. However, the optimal radiation fractionation regimen for localized prostate canc...

    Authors: Bin S. Teh, Gary D. Lewis, Weiyuan Mai, Ramiro Pino, Hiromichi Ishiyama and Edward Brian Butler
    Citation: Cancer Communications 2018 38:11
  40. Tissue specimens for nasopharyngeal carcinoma (NPC) research are scarce because of sampling difficulties. Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method fo...

    Authors: Pei-Fen Zhang, Xiao-Hui Zheng, Xi-Zhao Li, Tian Tian, Shao-Dan Zhang, Ye-Zhu Hu and Wei-Hua Jia
    Citation: Cancer Communications 2018 38:8
  41. Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal carcinoma in China. This study was to develop a staging model to predict outcomes of patients with ESCC.

    Authors: Jin-Cheng Guo, Yang Wu, Yang Chen, Feng Pan, Zhi-Yong Wu, Jia-Sheng Zhang, Jian-Yi Wu, Xiu-E Xu, Jian-Mei Zhao, En-Min Li, Yi Zhao and Li-Yan Xu
    Citation: Cancer Communications 2018 38:4