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Table 3. Molecular alterations in the PI3K pathway in subtypes of OC

From: The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges

OC subtype Molecular alteration in the PI3K pathway
High-grade serous PIK3CA amplification (25%)
PIK3CA mutation (<3%)
PIK3R1 mutation or copy number loss (2%)
AKT1/2/3 amplification (15%)
PTEN copy number loss (5%)
TSC1/2 mutation or loss (4%)
LKB1 (aka STK11) loss or mutation (2%)
Low-grade serous Rare
Mucinous Rare
Endometrioid PIK3CA mutation (20%)
PTEN loss (40%)
Clear cell PIK3CA mutation (35%)
  1. PI3K, phosphatidylinositol 3 kinase; PIK3CA, phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha; PTEN, phosphatase and tensin homolog; TSC, tuberous sclerosis complex; LKB1, liver kidney kinase B1.