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Table 3. Molecular alterations in the PI3K pathway in subtypes of OC

From: The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges

OC subtype

Molecular alteration in the PI3K pathway

High-grade serous

PIK3CA amplification (25%)

PIK3CA mutation (<3%)

PIK3R1 mutation or copy number loss (2%)

AKT1/2/3 amplification (15%)

PTEN copy number loss (5%)

TSC1/2 mutation or loss (4%)

LKB1 (aka STK11) loss or mutation (2%)

Low-grade serous

Rare

Mucinous

Rare

Endometrioid

PIK3CA mutation (20%)

PTEN loss (40%)

Clear cell

PIK3CA mutation (35%)

  1. PI3K, phosphatidylinositol 3 kinase; PIK3CA, phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha; PTEN, phosphatase and tensin homolog; TSC, tuberous sclerosis complex; LKB1, liver kidney kinase B1.