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Table 2. Histological and genomic features of the rare subtypes of epithelial ovarian cancer (OC)

From: The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges

OC rare subtype

Histological similarities

Oncogenic alterations

Low-grade serous

None

KRAS mutation (40%)

BRAF mutation (5%)

HER2 mutation (15%)

Mucinous

Mucinous intestinal tumors

KRAS mutation (50%)

BRAF mutation (5%)

HER2 amplification (15%)

Endometrioid

Endometrial cancer

PTEN mutation/loss (40%)

PIK3CA mutation (20%)

β-catenin mutation (40%)

Clear cell

Renal cell cancer

PIK3CA mutation (35%)

MET amplification (25%)

Transitional cell/Brenners tumors of the ovary

Urothelial tumors

NA

  1. NA, not available.