Table 1. Phenotypic-genotypic classification of ovarian carcinomas: 5 distinct diseases according to Prat[5]
Classification | Incidence | Median age (years) | Risk factor(s) | Precursor lesions | Molecular abnormalities | Pattern of spread | Chemosensitivity | Prognosis |
|---|---|---|---|---|---|---|---|---|
High-grade serous | 70% | 64 | BRCA1/2 | STIC | P53/BRCA | Very early transcoelomic | High | Poor |
Low-grade serous | <5% | 43 | NA | Borderline | BRAF, KRAS | Transcoelomic | Intermediate | Intermediate |
Mucinous | 3% | 45–50 | NA | Borderline | KRAS, HER2 | Typically confined to the ovary | Low | Favorable |
Endometrioid | 10% | 40–50 | Lynch syndrome | Endometriosis | PTEN, ARID1A | Typically confined to the pelvis | High | Favorable |
Clear cell | 5%–10% | 55 | Lynch syndrome +/− | Endometriosis | HNF1b, ARID1A, PIK3CA, MET | Typically confined to the pelvis | Low | Intermediate |