Table 2 Univariate and multivariate Cox regression analyses of clinicopathologic factors with overall survival in the SEER training set

Age (continuous)

1.017 (1.008–1.027)

< 0.001*

1.021 (1.012–1.031)

< 0.001*

1.018 (1.008–1.027)

< 0.001*

1.019 (1.009–1.028)

< 0.001*

Sex (male vs. female)

0.822 (0.617–1.096)

0.182

–

–

–

–

–

–

Tumor location (left vs. right)

0.981 (0.742–1.297)

0.892

–

–

–

–

–

–

Tumor size (continuous)

1.012 (0.993–1.032)

0.227

–

–

–

–

–

–

7th AJCC T stage

< 0.001*

< 0.001*

 T1

Reference

Reference

–

–

–

–

–

 T2

1.521 (0.734–3.154)

0.260

1.544(0.743–3.208)

0.244

–

–

–

–

 T3

3.412 (1.636–7.116)

0.001*

2.981 (1.428–6.225)

0.004*

–

–

–

–

 T4

4.364 (2.063–9.233)

< 0.001*

3.105 (1.454–6.633)

0.003*

–

–

–

–

7th AJCC N stage (N0 vs. N1)

3.448 (2.370–5.341)

< 0.001*

2.789 (1.801–4.319)

< 0.001*

–

–

–

–

7th AJCC M stage (M0 vs. M1)

2.773 (2.019–3.808)

< 0.001*

1.970 (1.391–2.791)

< 0.001*

–

–

–

–

7th AJCC TNM stage

< 0.001*

< 0.001*

 I

Reference

–

–

Reference

–

–

 II

1.297 (0.622–2.705)

0.489

–

–

1.196 (0.572–2.498)

0.634

–

–

 III

2.599 (1.225–5.515)

0.013*

–

–

2.375 (1.117–5.049)

0.025*

–

–

 IV

4.097 (1.976–8.498)

< 0.001*

–

–

3.897 (1.878–8.087)

< 0.001*

–

–

ENSAT stage group

< 0.001*

 I

Reference

–

–

–

–

Reference

< 0.001*

 II

1.297 (0.622–2.706)

0.488

–

–

–

–

1.191 (0.570–2.489)

0.642

 III

2.782 (1.339–5.779)

0.006*

–

–

–

–

2.545 (1.223–5.299)

0.013*

 IV

4.891 (2.317–10.322)

< 0.001*

–

–

–

–

4.752 (2.251–10.034)

< 0.001*