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Table 2 Univariate and multivariate Cox regression analyses of clinicopathologic factors with overall survival in the SEER training set

From: A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery: a retrospective analysis and multicenter validation study

CharacteristicsUnivariable analysesModel 1
Multivariable analyses
Model 2
Multivariable analyses
Model 3
Multivariable analyses
HR (95%CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
Age (continuous)1.017 (1.008–1.027)< 0.001*1.021 (1.012–1.031)< 0.001*1.018 (1.008–1.027)< 0.001*1.019 (1.009–1.028)< 0.001*
Sex (male vs. female)0.822 (0.617–1.096)0.182
Tumor location (left vs. right)0.981 (0.742–1.297)0.892
Tumor size (continuous)1.012 (0.993–1.032)0.227
7th AJCC T stage < 0.001* < 0.001*    
 T1Reference Reference
 T21.521 (0.734–3.154)0.2601.544(0.743–3.208)0.244
 T33.412 (1.636–7.116)0.001*2.981 (1.428–6.225)0.004*
 T44.364 (2.063–9.233)< 0.001*3.105 (1.454–6.633)0.003*
7th AJCC N stage (N0 vs. N1)3.448 (2.370–5.341)< 0.001*2.789 (1.801–4.319)< 0.001*
7th AJCC M stage (M0 vs. M1)2.773 (2.019–3.808)< 0.001*1.970 (1.391–2.791)< 0.001*
7th AJCC TNM stage < 0.001*   < 0.001*  
 IReference Reference 
 II1.297 (0.622–2.705)0.4891.196 (0.572–2.498)0.634
 III2.599 (1.225–5.515)0.013*2.375 (1.117–5.049)0.025*
 IV4.097 (1.976–8.498)< 0.001*3.897 (1.878–8.087)< 0.001*
ENSAT stage group < 0.001*      
 IReference Reference< 0.001*
 II1.297 (0.622–2.706)0.4881.191 (0.570–2.489)0.642
 III2.782 (1.339–5.779)0.006*2.545 (1.223–5.299)0.013*
 IV4.891 (2.317–10.322)< 0.001*4.752 (2.251–10.034)< 0.001*
  1. TCGA the Cancer Genome Atlas, AJCC the American Joint Committee on Cancer, ENSAT European Network for the Study of Adrenal Tumors, HR Hazard Ratio, CI confidence interval
  2. *P < 0.05