Table 2 Multivariate Cox regression analysis including all variables without surgery type for overall survival of hepatoblastoma patients
From: Incidence trends and survival prediction of hepatoblastoma in children: a population-based study
| Characteristic | HR | 95% CI | P value |
|---|---|---|---|
| Sex | |||
| Male | Reference | ||
| Female | 0.72 | 0.44–1.18 | 0.195 |
| Ethnicity | |||
| Caucasian | Reference | ||
| African–American | 2.88 | 1.55–5.36 | 0.001 |
| Others | 1.02 | 0.54–1.94 | 0.947 |
| Age at diagnosis (years) | |||
| 0–1 | Reference | ||
| 2–4 | 1.64 | 1.03–2.61 | 0.038 |
| 5–18 | 1.06 | 0.41–2.71 | 0.909 |
| Year of diagnosis | |||
| 2004–2007 | Reference | ||
| 2008–2011 | 0.68 | 0.40–1.16 | 0.155 |
| 2012–2015 | 0.84 | 0.47–1.48 | 0.540 |
| Tumor size | |||
| ≤ 5 cm | Reference | ||
| > 5 cm | 3.81 | 0.92–15.72 | 0.065 |
| Unknown | 6.13 | 1.39–27.09 | 0.017 |
| Tumor stage | |||
| Local | Reference | ||
| Regional | 2.04 | 1.10–3.79 | 0.024 |
| Distant | 3.42 | 1.87–6.26 | < 0.001 |
| Unstaged | 2.49 | 0.77–8.07 | 0.129 |
| AFP status | |||
| Negative | Reference | ||
| Positive | 2.19 | 0.30–16.15 | 0.442 |
| Unknown | 3.01 | 0.39–23.18 | 0.291 |