Table 3 Multivariate analyses of overall survival in additional independent cases of BRCA, LIHC, LUAD, STAD, and ESCA
Cancer type | Characteristic | Total (cases) | PGK1 pS203 | PDHK1 pT338 | ||
|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |||
BRCA | TNBCa | |||||
 No | 109 | 1.000 |  | 1.000 |  | |
 Yes | 24 | 2.561 (1.205–5.444) | 0.014 | 2.532 (1.191 to 5.383) | 0.016 | |
TNM stageb | ||||||
 I/II | 95 | 1.000 |  | 1.000 |  | |
 III/IV | 48 | 2.241 (1.172–4.286) | 0.015 | 2.238 (1.174 to 4.265) | 0.014 | |
PGK1 pS203 | ||||||
 Low | 65 | 1.000 |  |  |  | |
 High | 80 | 1.596 (0.805–3.168) | 0.181 |  |  | |
PDHK1 pT338 | ||||||
 Low | 66 |  |  | 1.000 |  | |
 High | 79 |  |  | 1.661 (0.837 to 3.298) | 0.147 | |
LIHC | TNM stagec | |||||
 I/II | 73 | 1.000 |  | 1.000 |  | |
 III/IV | 104 | 2.853 (1.878 to 4.335) | 0.000 | 2.905 (1.910 to 4.419) | 0.000 | |
PGK1 pS203 | ||||||
 Low | 107 | 1.000 |  |  |  | |
 High | 78 | 1.574 (1.064 to 2.327) | 0.023 |  |  | |
PDHK1 pT338 | ||||||
 Low | 105 |  |  | 1.000 |  | |
 High | 80 |  |  | 2.060 (1.390 to 3.052) | 0.000 | |
LUAD | TNM stage | |||||
 I/II | 105 | 1.000 |  | 1.000 |  | |
 III/IV | 74 | 1.805 (1.267 to 2.570) | 0.001 | 1.828 (1.284 to 2.602) | 0.001 | |
PGK1 pS203 | ||||||
 Low | 74 | 1.000 |  |  |  | |
 High | 105 | 1.800 (1.238 to 2.617) | 0.002 |  |  | |
PDHK1 pT338 | ||||||
 Low | 75 |  |  | 1.000 |  | |
 High | 104 |  |  | 1.634 (1.129 to 2.364) | 0.009 | |
STAD | Age (years) | |||||
 ≤ 60 | 56 | 1.000 |  | 1.000 |  | |
 > 60 | 39 | 2.258 (1.441 to 3.538) | 0.000 | 2.255 (1.436 to 3.540) | 0.000 | |
TNM staged | ||||||
 I/II | 24 | 1.000 |  | 1.000 |  | |
 III/IV | 69 | 3.382 (1.957 to 5.843) | 0.000 | 3.314 (1.920 to 5.720) | 0.000 | |
PGK1 pS203 | ||||||
 Low | 51 | 1.000 |  |  |  | |
 High | 44 | 2.603 (1.630 to 4.155) | 0.000 |  |  | |
PDHK1 pT338 | ||||||
 Low | 49 |  |  | 1.000 |  | |
 High | 46 |  |  | 2.397 (1.501 to 3.829) | 0.000 | |
ESCA | Age (years) | |||||
 ≤ 60 | 112 | 1.000 |  | 1.000 |  | |
 > 60 | 102 | 1.657 (1.146 to 2.397) | 0.007 | 1.614 (1.114 to 2.338) | 0.011 | |
TNM stage | ||||||
 I/II | 98 | 1.000 |  | 1.000 |  | |
 III/IV | 116 | 6.041 (3.867 to 9.437) | 0.000 | 6.022 (3.852 to 9.415) | 0.000 | |
PGK1 pS203 | ||||||
 Low | 103 | 1.000 |  |  |  | |
 High | 111 | 1.440 (0.997 to 2.079) | 0.052 |  |  | |
PDHK1 pT338 | ||||||
 Low | 94 |  |  | 1.000 |  | |
 High | 120 |  |  | 1.453 (0.996 to 2.119) | 0.053 | |